background and aims. various morphologies are seen in different salivary gland tumorsor within an individual tumor, and the lesions show divers biological behaviors. experimental results support the hypothesis that increased crkii proto-oncogene is associated with cytokine-induced tumor initiation and progression by altering cell motility signaling pathway. the aim of this study was to assess t...

background: information regarding solid pseudopapillary neoplasm (spn) of the pancreas is limited in iran. we aimed to review the clinicocytopathological features and follow-up of patients with spn of pancreas who were diagnosed in a single center in iran. methods: seven patients with spn of the pancreas were diagnosed during january 2010 to march 2015 at the digestive disease research institut...

Im • mu • no • his • to • chem • is • try (n.) Microscopic localization of specific antigens in tissues by staining with antibodies labeled with fluorescent or pigmented material. Immunohistochemistry (IHC) is a method used to determine the expression of biomarkers in tissue. This educational guidebook will describe immunohistochemistry as it is used in the pathology laboratory as an aid in the...

CONTEXT The increasing demand for immunohistochemistry for clinical diagnostics, in combination with an ongoing shortage of staff in the histology laboratory, has brought about a need for automation in immunohistochemistry. The current automated staining platforms vary significantly in their design and capabilities. OBJECTIVE To review how technology has been applied to automating the process...

This article summarized immunohistochemistry methods generally used in research laboratories and clinic including direct immune staining, indirect immune staining, enzyme method, fluorescence method, APC method and PAP method.

The Drosophila pupal abdomen is an established model system for the study of epithelial morphogenesis and the development of sexually dimorphic morphologies. During pupation, which spans approximately 96 hours (at 25 °C), proliferating populations of imaginal cells replace the larval epidermis to generate the adult abdominal segments. These imaginal cells, born during embryogenesis, exist as la...

background: vascular endothelial growth factor (vegf) is a signal protein produced by cells that stimulates angiogenesis and increased vascular permeability. the prognostic value of vegf expression in colorectal cancer is unclear as shown by the discordant results still reported in the literature. this study was designed for the evaluation of vegf expression and correlation with clinicopatholog...

background: the aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. methods: human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. full thickness of human normal endometrial sections and cultured endometrial cells ...

tendon never restores the complete biological and mechanical properties after healing. bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. stromal vascular fraction (svf), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

kaposiform hemangioendothelioma (khe) appears as a single lesion at birth or early infancy in an equal sex ratio. a rare aggressive vascular proliferation has been recognized as a separate entity from other childhood vascular neoplasm. a 3-year-old iranian boy with a rapidly enlarging mass in his (posterior aspect of skull at the midline) skull was present here. physical examination revealed a ...