BACKGROUND Psychosis associated with stimulant use is an increasing problem, but there is little research evidence about the nature of the problem and its management. AIMS To critically review the literature on stimulant psychosis and sensitisation. METHOD Systematic review of studies that have investigated stimulant use and psychosis in humans. The main outcome measures were increases in p...

BACKGROUND Attention-deficit hyperactivity disorder (ADHD) is linked to increased risk for substance use disorders and nicotine dependence. AIMS To examine the effects of stimulant treatment on subsequent risk for substance use disorder and nicotine dependence in a prospective longitudinal ADHD case-control study. METHOD At baseline we assessed ADHD, conduct disorder and oppositional defian...

BACKGROUND Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in children, with worldwide prevalence of ADHD varying from 5.9 to 7.1 %, depending on the reporter. In case of inadequate response to stimulants, combination therapy of stimulants and an adjunctive medication may improve the control of ADHD symptoms, reduce the dose-limiting adverse events, and help con...

In spite of tremendous strides in modern medicine there has been no drug that stimulates the function of the liver, protects it from damage or helps in the regeneration of hepatic cells. Liv.52 is reported to be a powerful hepatic stimulant and choleretic which increases the functional capacity of the liver and accelerates cellular metabolic activity and promotes regeneration and shows marked l...

Obesity and overweight are major health issues. Exercise and calorie intake control are recognized as the primary mechanisms for addressing excess body weight. Naturally occurring thermogenic plant constituents offer adjunct means for assisting in weight management. The controlling mechanisms for thermogenesis offer many intervention points. Thermogenic agents can act through stimulation of the...

Phage display-mediated immuno-polymerase chain reaction (PD-IPCR) is an ultrasensitive detection technology that combines the advantages of immuno-PCR and phage display. The phage particle, which displayed antibody fragments including single-chain fragment variable (scFv), variable domain of heavy-chain antibodies (VHH), and antigen-binding fragment (Fab) on the surface can be directly used in ...

Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective, hence driving the demand for new experimental therapeutics. The antiproliferative capacity of proteasome inhibitors (PIs) has received considerable attention given the success of their first prototypical representative, bortezomib (BTZ), ...

Use of illicit stimulant drugs such as methamphetamine, cocaine, and ecstasy are a significant worldwide problem. However, little is known about the effect of these drugs on movement. The aim of the current study was to investigate hand function in adults with a history of illicit stimulant use. We hypothesized that prior use of illicit stimulant drugs is associated with abnormal manipulation o...

Submitted 2 Proteasome inhibitors in experimental therapeutics of autoimmune diseases Submitted 28 Abstract Current treatment strategies for rheumatoid arthritis (RA) consisting of disease modifying antirheumatic drugs or biological agents are not always effective , hence driving the demand for new experimental therapeutics. The anti-proliferative capacity of proteasome inhibitors (PIs) has rec...