Abstract AIMS The kynurenine (Kyn) pathway plays an important role in the pathogenesis of many cancers including glioblastomas (GBMs). enzymes, indoleamine-2,3-dioxygenase (IDO1) and tryptophan-2,3-dioxygenase (TDO2), regulate first rate-limiting step resulting formation N-formyl-kynurenine, which is then readily converted into Kyn by formaldehyde. Cancers expressing IDO1 TDO2 enzymes can produ...

Summary. Aim. To study the condition of phagocytic part immunity in cholangitis. One main ways elimination bacterial contamination body is work immune system, namely phagocytosis. This especially applies to acute and chronic cholangitis.
 Materials methods. Depending on magnitude pathological changes biliary we have identified three groups patients whom cholangitis occurs conditions that p...

Summary The sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step PINK1/Parkin mitophagy. ATG4 family proteases are thought to regulate autophagosome formation exclusively by processing the ubiquitin-like ATG8 (LC3/GABARAPs). We discover that human ATG4s promote independently their protease activity and processing. proximity network...

screening of3000 soil samples collected from cities of four different provinces of iran for starch-hydrolysing bacteria revealed that the nature is enriched with streptomyces species capable of producing amylolytic enzymes. among the bacterial isolates, one of the high starch-degrading strains was selected for further microbiological identification and also amylolytic enzyme(s) characterization...

studies have demonstrated that plant extracts possess various biological characteristics, including immunomodulatory activity. heracleum persicum desf. (apiaceae), a medicinal plant native to iran, was studied for its immunomodulatory activity. immunomodulatory activity of different doses of an aqueous extract of h. persicum, was evaluated in female swiss albino mice. mice were treated with thr...

Improvement of properties by immobilization http://www.scitopics.com/IMPROVEMENT_OF_ ENZYME_PROPERTIES_VIA_IMMOBILIZATION_ TECHNIQUES.html This webpage focuses on the means by which enzyme activity can be stabilized or improved in an immobilized state compared with the same enzyme free in aqueous solution. Immobilized enzymes http://www.rpi.edu/dept/chem-eng/Biotech-Environ/viet/ nelly.html Thi...

Essential oils from different plant species were found to contain compounds exhibiting anti-inflammatory effects with the potential be a valid alternative conventional chemotherapy that is limited in long-term use due its serious side effects. Generally, first mechanism by which an organism counteracts injurious stimuli inflammation, considered part of innate immune system. Periodontitis infect...

Abstract Background Plant growth regulators are widely used in agriculture for increasing the and ripening of plants, but they endanger aquatic ecosystem. The current study assessed effect sublethal exposure to RIPEX 48% EC concentrations (8 16 µL/L) on oxidative stress parameters, sex hormones, immune potential enzymes, differential hemocyte counts, histopathology digestive glands ovotestis Bi...

site-directed mutagenesis (sdm) as a powerful technique was used to change two important and conserved amino acids in 5-enolpyruvylshikimate 3- phosphate synthase (epsps) gene of e. coli. the mutations changed glycine 96 to alanine and alanine 183 to threonine. these two amino acids are very important for intraction of the wide spectrum herbicide, glyphosate, to epsp synthase enzymes. by design...

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that have independently evolved to catalyze the first step in tryptophan catabolism via the kynurenine pathway (KP). The depletion of tryptophan and formation of KP metabolites modulates the activity of the mammalian immune, reproductive, and central nervous systems. IDO and TDO enzymes can h...