Over the past decade, it was widely accepted that some chemotherapeutic drugs can be combined with immunotherapeutic drugs in treatment of cancer. Chemotherapeutic drugs can induce apoptosis in the tumor cell and at the same time stimulate the immune response. Several reports support the use   immunomodulators in treatment of cancers through regulating the immune response and boosting the micro...

conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...

In multiple sclerosis (MS) beneficial effects have been assigned to the interferon (IFN)-I subclass IFN-ß, making its administration a first-line disease-modifying treatment in MS. IFN-I responses can be induced by cyclic-dinucleotide (CDN) triggered activation of Stimulator-of-interferon-genes (STING) and have essential immunomodulatory effects. A beneficial effect of STING activation on...

Background: Long-term and intensive physical exercise can change the function of different cells in the immune system in athletes, predisposing them to viral infections such as coronavirus disease (COVID-19). The purpose of this brief report was to provide protocols related to the immune system in athletes to prevent infectious diseases. Methods: To examine immune system res...

background: atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. regulatory t cells (treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. quantitative and/or functional alteration of tregs has been shown to play an atheroprotective role and may al...

One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...

evidence showed that chemokines serve as pro-migratory factors for immune cells. ccl3, ccl4 and ccl5, as the main cc  chemokines subfamily members, activate immune cells through binding to cc chemokine receptor 5 or ccr5. macrophages, nk cells and t lymphocytes express ccr5 and thus, affected ccr5 expression or functions could be associated with altered immune responses. deletion of 32 base pai...