The present study is to establish bi-layer tablets of Glimepiride and Captopril, of which Glimepiride as immediate release and Captopril as sustained release layers. Immediate release layer was prepared by direct compression method by using cross povidone as disintegrant and sustained release layer was prepared by direct compression method by using HPMC K4 as polymer. Both powder blends of imme...

BACKGROUND The effects of opioid medication on cognitive functioning in patients with cancer and non-cancer pain remain unclear. METHOD In this mechanistic randomized, double-blind, placebo-controlled, cross-over study of patients (n = 20) receiving sustained-release and immediate-release opioid medication as part of their palliative care, we examine memory effects of an additional dose of pa...

The term “immediate release” pharmaceutical formulation includes any in which the rate of release drug from or absorption drug, is neither appreciably, nor intentionally, retarded by galenic manipulations. These tablets disintegrate rapidly and get dissolved to medicaments. It may be provided for way an appropriate pharmaceutically acceptable diluent carrier, carrier does not prolong, appreciab...

In diacetylmorphine prescription programs for heavily dependent addicts, diacetylmorphine is usually administered intravenously, but this may not be possible due to venosclerosis or when heroin abuse had occurred via non-intravenous routes. Since up to 25% of patients administer diacetylmorphine orally, we characterised morphine absorption after single oral doses of immediate and extended relea...