Rat choriocarcinoma (Rcho) cells, which are morphologically similar to trophoblast giant cells of the normal placenta and produce placental lactogen-I in vivo, were used to investigate placental feedback on PRL secretion and tuberoinfundibular dopaminergic neuronal activity. Rcho cells were injected into female rats either intracerebroventricularly 60-65 h before use or under the kidney capsule...

Quinolone-induced chondrotoxicity was demonstrated in juvenile rats and multiple other species. Identical damages can be induced in immature rats by feeding a magnesium-deficient diet. The objective of the present study was to investigate whether in reverse the oral supplementation with magnesium, vitamin E or both can diminish the typical quinoloneinduced arthropathy in juvenile Wistar rats. F...

New neuron production throughout adulthood in granule cell layer (GCL) of rat hippocampus is a well-known phenomenon. A role of new neurons in hippocampal learning has been proposed, but the question is still open. A reduction of neural precursor proliferation in GCL of 2-month-old rats to about 20%, induced by the cytostatic agent methylazoxymethanol, was found to cause impairment in trace con...

Cyclophosphamide is one of the chemotherapeutics for cancer, however this drug has severe side effects in multiple organs and a well-known mutagenic agent. In work protective activity antioxidant-rich Carob (Ceratonia siliqua L.) pods leaves extracts against cyclophosphamide induced genotoxicity was studied. Safety these evaluated acute subacute toxicity tests at dose 1500 mg/kg/day albino rats...

Abstract Background Blood coagulation has been associated with ovulation and female infertility. In this study, the expression of tissue factor system was examined during in immature rats; correlation between ovarian hyperstimulation syndrome (OHSS) evaluated both rats human follicular fluids. Methods Ovaries were obtained at various times after chorionic gonadotropin (hCG) injection to investi...

Introduction: Motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. This study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. Methods: Neonate rats (n=56) were rand...