The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was...

The roots of Rumex nepalensis spreng (Family-Polygonaceae) were studied to fix the parameters for Pharmcognostical standards. The present investigation deals with the macrocopical characters of root as well as studies on some physical constants, behavior of powdered root on treatment with different chemical reagents and fluorescence characteristics on exposure to ultra -violet light. These stud...

Imipenem is renally metabolized to the stable open-lactam metabolite by a dipeptidase, dehydropeptidase I, located at the lumenal surface of the proximal tubular cells. In humans the degree of hydrolysis shows marked intersubject variability but minimal intrasubject variability. In healthy subjects the urinary recovery of unchanged imipenem ranged from 5.5% to 42.5% of the dose. Cilastatin inhi...

A significant increase in summer temperatures has been observed for the period 1996-2011 in Poznań, Poland. The phenological response of four weed taxa, widely represented by anemophilous species (Artemisia spp., Rumex spp. and Poaceae and Urticaceae species) to this recent climate warming has been analysed in Poznań by examining the variations in the course of airborne pollen seasons. Pollen d...