BACKGROUND Numerous agents have been demonstrated to potentiate morphine analgesia, including clonidine (alpha(2)-adrenergic and I(1)-imidazoline receptor agonist) and BMS182874 (endothelin-A, ET(A,) receptor antagonist). ET has been shown to affect pharmacological actions of clonidine. The present study was conducted to determine whether alpha(2)-adrenergic and/or I(1)-imidazoline receptors ar...

Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathetic activation and reverses LVH. We h...

Two types of chelating fibers containing an imidazoline or thioamide group were prepared through the functionalization of hydrazine-modified polyacrylonitrile fiber by ethylenediamine and through the amination and sulfurization reaction of the hydrazine-modified polyacrylonitrile fiber under appropriate conditions, respectively. It is shown that the reaction temperature, time, and agent concent...

BACKGROUND We have recently described the synthesis and circulatory properties of two novel centrally acting imidazoline agents: marsanidine (1-[(imidazolidin-2-yl)imino]indazole) and 7-Me-marsanidine (1-[(imidazolidin-2-yl)imino]-7-methylindazole). Marsanidine has proven to be a highly selective α2-adrenoceptor ligand with the α2/I1 selectivity ratio of 3879, while 7-Me-marsanidine has been sh...

DABCO-catalyzed [3 + 2] annulation reaction of sulfamate-derived cyclic imines with isocyanoacetate proceeds under mild conditions, providing sulfamate-fused 2-imidazolines in moderate to excellent yields with moderate to excellent diastereoselectivities.

The photochromic reaction of a diarylethene derivative having imidazoline rings reversibly modulates the dielectric properties of the crystal, which is based on the intermolecular proton transfer in one-dimensional (1D) hydrogen-bonded chains.

In the crystal of the title compound, 2CH(6)N(3) (+)·2Cl(-)·C(12)H(24)O(6), the 18-crown-6 mol-ecule is located across an inversion center. The guanidinium cation links to the 18-crown-6 mol-ecule and chloride anion via N-H⋯O and N-H⋯Cl hydrogen bonds.

Imidazoline compounds have been considered for the treatment of type 2 diabetes. We have now investigated the effects of imidazolines on interleukin (IL)-1 –induced -cell apoptosis and the signal transduction pathways involved. Inhibition of Ca influx into -cells by D-600, a blocker of voltage-gated L-type Ca channels, suppressed IL-1 –induced apoptosis. Our data show that calcineurin, Ca/calmo...

The I(1)-imidazoline receptor is a novel target for drug development for hypertension and insulin resistance, major disorders associated with type 2 diabetes. In the present study, we examined the effects of a novel imidazoline agonist S43126, on phosphorylation of protein kinase B (PKB/Akt) and extracellular signal-regulated kinase (ERK1/2) in PC12 cells. We further examined the effects of S43...

In the title mol-ecular salt, (CH(6)N(3))(1.30)[Zn(H(2)O)(6)](0.35)[Zn(C(7)H(4)NO(4))(3)](2), the Zn(II) atom (site symmetry 3) in the anion is coordinated by three N,O-bidentate 3-carb-oxy-pyridine-2-carboxyl-ate monoanions to generate a fac-ZnN(3)O(3) octa-hedral coordination geometry. The guanidinium cation (the C atom has site symmetry 3) and the octa-hedral hexa-aqua-zinc(II) dication (the...