نتایج جستجو برای: imidazolidine 2

تعداد نتایج: 2525346  

2011
Augusto Rivera Diego Quiroga Jaime Ríos-Motta Karla Fejfarová Michal Dušek

The title compound, C(29)H(38)N(2)O(6), was prepared as model for studying intra-molecular hydrogen-bonding inter-actions. Mol-ecules of the title compound are located on a crystallographic twofold rotation axis, which passes through the C atom linked to the two N atoms on the imidazolidine ring. The mol-ecular structure shows the existence of two intra-molecular O-H⋯N hydrogen-bonding inter-ac...

2007
Lin Li Yan-Hong Tian Chu-Yi Yu Li-Ben Wang

In the title compound, C(14)H(15)N(3)O(2), the C=C(H)-C=O grouping and the imidazolidine ring are coplanar as a result of an intra-molecular N-H⋯O hydrogen bond and extended electronic conjugation. Inter-molecular N-H⋯O and O-H⋯N hydrogen bonds help to establish the packing.

2009
Qing-Fan Xie Miao-Ling Huang Yan-Min Chen

In the title centrosymmetric dinuclear complex, [Nd(2)(C(27)H(24)Br(3)N(4)O(3))(2)]·6C(3)H(7)NO, the Nd(III) ion is coordinated in a slightly distorted square-anti-prismatic geometry by four N atoms and four O atoms from two centrosymmetrically-related 1,3-bis-[2-(5-bromo-2-oxidobenzyl-amino)eth-yl]-2-(5-bromo-2-oxidophen-yl)-1,3-imidazolidine ligands. The Nd⋯Nd separation is 4.5012 (12) Å.

Journal: :Bioorganic & medicinal chemistry letters 2015
Yan A Ivanenkov Sergei V Vasilevski Elena K Beloglazkina Maksim E Kukushkin Alexey E Machulkin Mark S Veselov Nina V Chufarova Elizaveta S Chernyaginab Anton S Vanzcool Nikolay V Zyk Dmitry A Skvortsov Anastasia A Khutornenko Alexander L Rusanov Alexander G Tonevitsky Olga A Dontsova Alexander G Majouga

Regioselective synthesis, biological evaluation and 3D-molecular modeling for a series of novel diastereomeric 2-thioxo-5H-dispiro[imidazolidine-4,3-pyrrolidine-2,3-indole]-2,5(1H)-diones are described. The studied compounds have been tentatively identified as potent small molecule MDM2/p53 PPI inhibitors and can therefore be reasonably regarded as promising anticancer therapeutics.

2008
Xiao-Zhong Feng Fu-Feng Yan Zhen-Ping Li

In the title mol-ecule, C(20)H(18)N(4), the imidazolidine ring makes dihedral angles of 86.74 (2) and 81.18 (3)° with the two phenyl rings. In the absence of classical inter-molecular inter-actions, the crystal packing is stabilized by van der Waals forces.

Journal: :Acta poloniae pharmaceutica 2014
Agnieszka Zagórska Anna Czopek Karolina Pełka Krystyna Stanisz-Wallis Maciej Pawłowski

The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that R(M0) of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2...

Journal: :Molecules 2015
Tomasz M Wróbel Urszula Kosikowska Agnieszka A Kaczor Sylwia Andrzejczuk Zbigniew Karczmarzyk Waldemar Wysocki Zofia Urbańczyk-Lipkowska Maja Morawiak Dariusz Matosiuk

Six novel imidazoline derivatives were synthesized and tested in antifungal assays. One of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide showed moderate activity against several clinical strains of Candida albicans. Its structure was solved by X-ray crystallography and its mode of action was deduced using molecular modelling. It was found to be similar to that...

2009
Zhenfeng Zhang Jiange Wang Guisheng Zhang

In the title compound, C(17)H(18)N(2)O(4)S, where one of the N-4-methoxy-phenyl fragments is disordered over two sets of sites, the five-membered ring exhibits a nearly half-chair conformation and the two hydroxyl groups lie on opposite sides of the five-membered ring. In the crystal, the mol-ecules are linked into sheets parallel to (100) via O-H⋯O and O-H⋯S hydrogen bonds.

2008
MOHAMMED I. M. WAZEER ANVARHUSEIN A. ISAB

Reactions of imidazolidine-2-thione (Imt), 1,3-diazinane-2-thione (Diaz) and 1,3-diazipane-2thione (Diap) with mercury(II) selenocyanate in acetonitrile resulted in formation of 2 : 1 complexes. Both solid state and solution NMR, confirm the exocyclic sulfur atom to be the donor in all cases. Hg shielding tensors and anisotropies were calculated from the solid-state NMR spectra. Based on the so...

2011
Augusto Rivera Diego Quiroga Jaime Ríos-Motta Karla Fejfarová Michal Dušek

In the crystal structure of the title compound, C(21)H(24)I(2)N(2)O(2), the two N atoms of the imidazolidine moiety are linked to the hy-droxy groups by intra-molecular O-H⋯N hydrogen-bonding inter-actions. The cyclo-hexane ring adopts a chair conformation and the heterocyclic ring to which it is fused has a twisted envelope conformation.

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