CD4+ T cells are essential for development and perpetuation of Crohn's disease, a chronic immune-mediated condition that affects primarily the small intestine. Using novel models of Crohn's disease-like ileitis (i.e., SAMP1/YitFc and CD4+ T cell transfer models), we have begun to understand the adhesive pathways that mediate lymphocyte trafficking to the chronically inflamed small bowel. Expans...

Background and aims: Recently, magnetic resonance imaging (MRI) has been introduced in the diagnosis of patients with inflammatory bowel disease (IBD). However, it is still rarely reported in paediatric IBD. We studied the diagnostic value of gadolinium enhanced MRI in revealing inflammation of the distal ileum in children with Crohn’s disease (CD) and in differentiating them from patients with...

Two Zambian infants presented with massive rectal bleeding caused by cytomegalovirus ileitis. The first was seropositive for HIV and the second seronegative, though her mother was seropositive. Both infants died.

In the early years after the recognition of regional enteritis by Crohn and his colleagues1, surgical treatment was considered curative and excision of the affected bowel the ideal treatment. During the next 10 years the high recurrence rate after surgery worried physicians and disillusioned surgeons and so Crohn's disease came to be regarded as something of a surgical enigma2. The surgeon enco...

Ulcerative colitis (UC) is a form of inflammatory bowel disease that typically involves the colorectum; it has been reported that a certain proportion of patients with UC also develop ileitis, leading to ileal perforation in very extreme cases. We report a 66-year-old male with UC who presented with ileal perforation eight days after proctocolectomy. Although this situation is very rare, differ...

Enteroendocrine cells act as sensory transducers, releasing 5-HT and numerous peptides that are involved in regulating motility, secretion, and gut sensation. The action of mucosal 5-HT is terminated by a 5-HT reuptake transporter (SERT). In this study, we examined the hypothesis that ileitis leads to changes in enteroendocrine cell populations and mucosal 5-HT availability. Ileitis was induced...

Enteroendocrine cells act as sensory transducers, releasing serotonin (5-HT) and numerous peptides that are involved in regulating motility, secretion and gut sensation. The action of mucosal 5-HT is terminated by a serotonin reuptake transporter (SERT). In this study we examined the hypothesis that ileitis leads to changes in enteroendocrine cell populations and mucosal serotonin availability....