Footrot is a common inflammatory bacterial disease affecting the health and welfare of sheep worldwide. The pathogenesis of footrot is complex and multifactorial. The primary causal pathogen is the anaerobic bacterium Dichelobacter nodosus, with Fusobacterium necrophorum also shown to play a key role in disease. Since immune-mediated pathology is implicated, the aim of this research was to inve...

PURPOSE This study evaluated the discriminatory power of salivary transcriptomic and proteomic biomarkers in distinguishing oral squamous cell carcinoma cases from controls and potentially malignant oral disorders (PMOD). EXPERIMENTAL DESIGN A total of 180 samples (60 OSCC patients, 60 controls, and 60 PMOD patients) were used in the study. Seven transcriptomic markers (IL8, IL1β, SAT1, OAZ1,...

Mononuclear cells play an important role in the modulation of healing. The characteristics of implant surface topography may alter the production of signaling molecules such as cytokines. The aim of this in vitro study was to evaluate the effects of commercially available titanium surface treatments on both cell viability and the secretion of the antagonist cytokines, IL1β and TGFβ1. Human mono...

Unconventional secretory proteins represent a subpopulation of extracellular factors that are exported from eukaryotic cells by mechanisms that do not depend on the endoplasmic reticulum and the Golgi complex. Various pathways have been implicated in unconventional secretion including those involving intracellular membrane-bound intermediates and others that are based on direct protein transloc...

The effectiveness of personalized therapy for rheumatoid arthritis (RA) is associated with the correct choice drug and ability to predict its effect before starting treatment. Objective : study in patients RA relationship between results initial expression genes responsible bone articular cartilage resorption (matrix metalloproteinase 9 – MMP9, cathepsin K) inflammation (tumor necrosis factor α...

Identifying the contact regions between a protein and its binding partners is essential for creating therapies that block the interaction. Unfortunately, such contact regions are extremely difficult to characterize because they are hidden inside the binding interface. Here we introduce protein painting as a new tool that employs small molecules as molecular paints to tightly coat the surface of...

The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical disease progression and tumor recurrence. ABCB5 confers therapeutic resistance, but other functions in tumorigenesis independent of drug efflux have not been described that might help explain why it is so broadly overexpressed in human cancer....

Common bean consumption is associated with the prevention of chronic diseases and these effects are partially attributed to their polyphenol content. In this study, bioaccessibility anti-inflammatory activity polyphenols from six Mexican cultivars beans (Phaseolus vulgaris) varying in seed colour, was evaluated. all cultivars, digestion starch protein released significantly more compared soakin...

Synovial biomarkers are increasingly important in the development of novel therapeutic agents for treatment rheumatoid arthritis (RA). To identify correlating with changes clinical disease activity, real-time quantitative PCR (Q-PCR) was used to evaluate synovial gene expression after corticosteroids. Patients active RA received either oral prednisolone (n = 10, 60 mg daily first week and 40 se...