background: this study was designed to evaluate whether or not t. gondii and its derivatives can change the gene expression level of il-10 in murine leukocytes in vivo.   methods: fifty balb/c mice were divided into 5 groups, four of which received the excretory/secretory product (esp) from cell culture medium, the esp from cell free medium, the toxoplasma lysate product (tlp) and the active ta...

background: pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (rm). objective: to investigate the association between rm and five polymorphisms of cytokine genes, interleukin 10 (il-10), (-592 a/c, -819 c/t, -1082 a/g), il-6 (-174 c/g) and il-17 (-197 g/a) in iranian women. method: po...

Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

interleukin-8 (il-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. this study investigates il-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the il-8 gene in a pakistani population.patients with acne vulgaris (n=264) and healthy individuals (n=264) were enrolled in this investigation....

Background & Objective: Interleukin (IL)-10 is an important anti-inflammatory and immunomodulatory cytokine. Some authors believe that single nucleotide polymorphisms (SNP) in the promoter region of the IL-10 gene have been associated with susceptibility to HIV infection and progression to AIDS, but its role is not clearly defined yet. The present study was undertaken to evaluate the a...

introduction: helicobacter pylori (h. pylori) infection has remained as a global health problem. animal studies demonstrated the role of h. pylori oipa gene in the development of gastric cancer. the aim of this study was the cloning and expression of helicobacter pylori oipa gene in a bicistronic vector harboring mice il-18 gene. materials and methods: the target gene encoding oipa was amplifie...

We introduce the class of Rγ-convex functions and discuss that it relates to some other classes convexity. study in perspective trapezium-like inequalities, for which we also derive a new integral identity involving k-th order differentiable function. In show significance our results, several special cases offer interesting applications.