Common environmental allergens stimulate IgE responses and produce allergic disease, but the allergens that produce the most potent IgE responses in nature originate from helminthic parasites. 1 2 Since parasitic infection is endemic in the majority of the world's population , the relationship between helminthic infection and the IgE response is highly relevant to the understanding of allergic ...

Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (FC epsilonRI) on the surface of mast cells with multivalent allergens results in the release of both pre-formed and newly generated mediators, and in the manifestation of allergic symptoms. The expression of Fc epsilonRI, and the synthesis of IgE are therefore critical for the development of allergic diseases. In th...

Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (Fc e RI) on the surface of mast cells with multivalent allergens results in the release of both preformed and newly generated mediators, and in the manifestation of allergic symptoms. The expression of Fc e RI, and the synthesis of IgE are therefore critical for the development of allergic diseases. In this study, w...

Studies of myeloma cell DNA and immunoglobulin synthesis and total body tumor cell number were performed on a patient with IgE multiple myeloma and plasma cell leukemia; results were contrasted to similar observations in patients with IgG myeloma. Autoradiographic studies demonstrated significantly greater DNA labeling in the IgE patient’s bone marrow plasma cells than in cells from IgG myeloma...

Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.

Parasitic infection is highly allergenic, and the present paper illustrates how parasites might disrupt the regulation of IgE synthesis, resulting in heightened Th-2 responses. The study of parasites, and dysregulation of the IgE network, could in turn provide information relating to the aetiology of allergic diseases such as asthma and atopic dermatitis.

Mast cells are pivotal effector cells in IgE-mediated allergic inflammatory diseases. Central for mast cell activation are signals from the IgE receptor FcepsilonRI, which induce cell degranulation with the release of preformed mediators and de novo synthesis of proinflammatory leukotrienes and cytokines. How these individual mast cell responses are differentially controlled is still unresolved...

Mast cells (MC) are major effector cells for allergic diseases. Cross-linking of immunoglobulin E (IgE) and its high-affinity receptor, Fc RI, by antigen initiates a cascade of signaling events leading to nuclear factor (NF)B activation and tumor necrosis factor (TNF) production. Here, we demonstrated that inhibition of inhibitor of B (I B) kinase (IKK) by a peptide IKK inhibitor or by four ind...