OBJECTIVES To provide evidence of underdiagnosis of coeliac disease and to describe the main presenting symptoms of coeliac disease in primary care. DESIGN Case finding in a primary care setting by testing for coeliac disease by using the endomysial antibody test. SETTING Nine surgeries in and around a market town in central England, serving a population of 70 000. PARTICIPANTS First 1000...

background : â  celiac disease (cd) is an immune-mediated inflammation of the small intestine caused by sensitivity to dietary gluten and related proteins in genetically sensitive individuals . recurrent aphthous stomatitis (ras) is an inflammatory condition characterized by painful recurrent, single or multiple ulcerations of the oral mucosa. the association between cd and ras has been evaluat...

BACKGROUND An increased prevalence of coeliac disease in patients with primary biliary cirrhosis has been recently reported. However, in other studies the association has not been confirmed. There have been no formal attempts to systematically evaluate patients with autoimmune cholangitis for coeliac disease. METHODS Sera from 62 patients with primary biliary cirrhosis, 17 with autoimmune cho...

This review determines the significance, usefulness, and application of the endomysial antibody test for coeliac disease in clinical practice.

Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patien...

BACKGROUND Coeliac disease has an increased prevalence in a number of autoimmune endocrine conditions. An association between coeliac disease and Addison's disease has been proposed in isolated case reports, but has not been formally studied. AIM To investigate the extent of this association. DESIGN Prospective screening of patients with confirmed Addison's disease. METHODS From central c...

BACKGROUND Aetiopathogenesis of psoriasis is complex and not yet well known. In recent years, it has been observed that psoriasis can coexist with clinically asymptomatic celiac disease and a gluten-free diet helps to obtain remission, even in patients with very chronic lesions. OBJECTIVE The aim of our work was to investigate how often the positive titres of antibodies characteristic for cel...

Sir, Serum IgA class anti-endomysial antibodies (EMA) are markers of coeliac disease and dermatitis herpetiformis (DH) and are useful in monitoring compliance to diet. Their overall sensitivity for the diagnosis of DH is about 80% and their specificity around 96% (1). As anti-gliadin antibodies (AGA) have already been reported in pemphigus (2, 3), the presence of AGA in another patient with pem...

Our prospective hospital-based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high-risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months-18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 (22.5%). Antigliadi...

Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently associated other autoimmune diseases, and its association with celiac disease (CD) is well established. In this article, we describe the case of a 50-year-old male with long-standing AIH taking azathioprine for 10 years, evaluated for flares in transaminases. Despite adding high-dose corticoste...