Tumor response to blood borne drugs is critically dependent on the efficiency of vascular delivery and transcapillary transfer. However, increased tumor interstitial fluid pressure (IFP) forms a barrier to transcapillary transfer, leading to resistance to drug delivery. We present here a new, noninvasive method which estimates IFP and its spatial distribution in vivo using contrast-enhanced mag...

The volume and fluid pressure characteristics of the intact bone marrow is incompletely understood. We used microspheres and lipoproteins for measurements of intravascular volume (IVV) and EDTA for interstitial fluid volume (IFV) within the rat bone marrow. Interstitial fluid pressure (IFP) was determined with micropipettes connected to a servo-controlled counter-pressure system. Both the micro...

Although Cai, Fürer and Immerman have shown that fixedpoint logic with counting (IFP + C) does not express all polynomialtime properties of finite structures, there have been a number of results demonstrating that the logic does capture P on specific classes of structures. Grohe and Mariño showed that IFP +C captures P on classes of structures of bounded treewidth, and Grohe showed that IFP + C...

Based on experimental pure component data for the characterization of isostructural imidazolate framework Potsdam (IFP) series reported in Part I, a model simulation non-isothermal dynamic adsorption CO2/CH4-mixtures fixed-bed columns is presented this II. The robustness examined and validated, by comparison to breakthrough at different process conditions, such as varying concentration, tempera...

Over the past decades a development of different anticancer drugs has increased and brought many progressive agents that showed high level of efficiency in in vitro conditions. Unfortunately these drugs failed in solid tumor treatment in in vivo conditions because of inadequate uptake and nonoptimal distribution in tumors. Although tumors have higher permeability and hydraulic conductivity of t...

The efficacy of present day antineoplastic regimens depends upon the delivery and penetration of therapeutic agents through the tumor vascular and interstitial spaces to the tumor cell target. The distribution of relevant molecules or cells in a solid tumor is often poor and heterogeneous and is believed to be due to a number of pathophysiological factors, including elevated interstitial fluid ...

Elevated interstitial fluid pressure (IFP) of tumors may be a physiological barrier to the delivery of certain therapeutic agents. The objective of this study was to find out if IFP could be lowered using localized hyperthermia and if the reduction in IFP could predict the tumor response to treatment. Amelanotic melanoma (A-Mel-3) implanted into the dorsal skin of Syrian golden hamsters was exp...

Chemotherapy of solid tumors is presently largely ineffective at dosage levels that are compatible with survival of the patient. Here, it is argued that a condition of raised interstitial fluid pressure (IFP) that can be observed in many tumors is a major factor in preventing optimal access of systemically administered chemotherapeutic agents. Using prostaglandin E1-methyl ester (PGE1), which i...