Introduction: The effects of the low dose of ionizing radiation are not thoroughly evident due to an unavoidable increase of occupational exposure and the widespread application of ionizing radiation in medical and industrial fields. The aim of this study was to investigate immune system responses following the low doses of ionizing radiation. Materia...

Background: Brucella is a gram-negative bacterium, causing acute and chronic infection in humans and animals. Cell-mediated immunity is the main protective immune response against Brucella spp. Activation of macrophages by IFN-γ and generation of reactive oxygen intermediates and nitric oxide are the main immunologic mechanisms responsible for control of Brucella infection. Objective: To invest...

The aim of this study was to investigate the immunomodulatory effects of Spirulina platensis (S.platensis) by measuring the levels of serum interleukin (IL)-4, IL-10, IL-17, tumor necrosis factor(TNF)-α and interferon (IFN)-|γ| in mice suffered from systemic candidiasis and breast cancer. Theaqueous extract of S. platensis was selected for this study. Balb/C female mice were inoculated withCand...

BACKGROUND: Interleukin-4 (IL-4) is a cytokine of Th2 response and plays role as reducer or silencer Th1 work. It more related to allergic processes, with consequent loss control the disease (i.e., tuberculosis). Interferon gamma (IFN-γ) Type II interferon that inhibits immune inducts inhibit tuberculous viral replication, any immunostimulatory immunomodulatory effects. Dark specks (DS) are in ...

BACKGROUND Treatment of HBV chronic carriers using interferon (IFN)-α or nucleoside/nucleotide analogues fails to suppress viral infection. Type-II IFN-γ has been shown to inhibit HBV replication. The goal of the present work was to evaluate the antiviral efficacy against HBV of a thermostable IFN-γ variant isolated using Massive Mutagenesis and thermoresistant selection (THR) technologies. M...

IFN-γ Receptor-Ligand Binding. IFN-γ binds to receptors on the macrophage surface, initiating a cascade of events leading to an increase in MHC class II expression (1). We assume that this increase is the primary mechanism by which IFN-γ facilitates antigen presentation. To represent IFN-γ receptor-ligand binding, we use the general reaction scheme ligand + receptor ↔ complex. Other processes a...