Spontaneous pregnancy loss is a surprisingly common occurrence, with approximately 15% of all clinically recognized pregnancies resulting in pregnancy failure. Recurrent pregnancy loss (RPL) has been inconsistently defined. When defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period, it affects approximately 1% to 2% of women. This review highlights the curre...

The majority of miscarriages are sporadic and most result from genetic causes that are greatly influenced by maternal age. Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies, and up to 50% of cases of RPL will not have a clearly defined etiology.

Background Accurate prevalence figures are not available, but it has been estimated that 1-2% of women have recurrent pregnancy loss (RPL), defined as three or more consecutive losses of intrauterine pregnancy in the first trimester. Half of whom have no identifiable cause. Recent studies of early pregnancy loss, preeclampsia, pregnancy complications such a hydatidiform mole suggests that these...

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...

BACKGROUND The management of recurrent pregnancy loss is uncertain. Some cohort studies have identified an association between inherited thrombophilias and recurrent or late non-recurrent pregnancy loss, which has prompted investigators to evaluate the benefit of low molecular weight heparin (LWMH) to achieve live birth. A similar benefit for LMWH has also been proposed independent of thromboph...

spontaneous abortion is the most common complication of pregnancy. several lines of evidence indicate that immunologic effector cells may play a role in the pathogenesis of idiopathic repetitive abortions. leukocytes form a substantial proportion of stromal cells in decidua and the endometrial granulated lymphocytes (egl) is the predominant decidual leukocyte population in the first trimester o...

Background: Recurrent pregnancy loss (RPL) is a common and distressing disorder. RPL is a devastating reproductive problem affecting approximately 5% of couples trying to conceive. If we camper the rate of miscarriage in couples may experience RPL with the pregnancy loss rate in general population we may calculate that it is at least two or three times higher than expected. This study aimed to ...