Background Autoantibodies against the 81-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of P1-blockade in some of these patients. Methods and Results Autoantibodies against ...

BACKGROUND The present investigation was designed to obtain an absolute measurement of myocardial blood flow and of its transmural distribution in ischemic heart disease and idiopathic dilated cardiomyopathy and to provide a reference standard for cardiac imaging in nuclear cardiology. METHODS AND RESULTS Regional myocardial blood flow and its transmural distribution were estimated by the ref...

Introduction Primary or idiopathic cardiomyopathy is a term used for a variety of conditions affecting the heart of both animals and man with no clearly identified cause. Although the term secondary cardiomyopathy has been used with specific causative factors such as ischemic cardiomyopathy, drug induced cardiomyopathy, toxic cardiomyopathy or infectious agent induced cardiomyopathy, recent cla...

BACKGROUND Previous studies of the prognosis of patients with heart failure due to cardiomyopathy categorized patients according to whether they had ischemic or nonischemic disease. The prognostic value of identifying more specific underlying causes of cardiomyopathy is unknown. METHODS We evaluated the outcomes of 1230 patients with cardiomyopathy. The patients were grouped into the followin...

Peripartum cardiomyopathy is defined as left ventricular dilation and failure, first developing during the third trimester of pregnancy or in the first 6 months postpartum. In an effort to characterize this syndrome in a middle class population, 14 consecutive patients with peripartum cardiomyopathy underwent a detailed history and physical examination, right heart catheterization, M-mode and t...

OBJECTIVES To report the rates of cardiomyopathies in the population below 50 years of age in Qatar. SUBJECTS AND METHODS We conducted a retrospective review of clinical data on patients with cardiomyopathy who were hospitalized in Hamad General Hospital, Doha. Data were collected from medical records during the 1996-2002 period and prospectively from the patients who were hospitalized during...

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