False lateralization of ictal onset by scalp EEG has been reported in patients with severe hippocampal sclerosis associated with hemispheric lesions or atrophy. There has been no report of cases of false lateralization by scalp EEG in patients without detectable structural abnormalities on MRI, or in patients with neocortical temporal lobe epilepsy. We report a case of false lateralization of i...

Perfusing rat hippocampal slices with high-K+ (7.5 mM) saline induced brief population bursts originating in CA3 at 0.5-1 Hz and spreading synaptically into CA1. In 42% of the slices the brief bursts evoked in CA1 gave way every 0.5-2 s to sustained ictal (or seizure) episode with tonic and clonic components. Paired intra- and extracellular recordings in the CA1 pyramidal layer were used to cha...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...

Electroencephalogram (EEG) recordings are often contaminated with muscle artifacts. These artifacts obscure the EEG and complicate its interpretation or even make the interpretation unfeasible. This paper focuses on the particular context of extraction of low-voltage rapid ictal discharges from ictal scalp-EEG activity cantaminated by muscle artifact. In this context our aim was to evaluate the...

We report a peculiar depth-EEG recording of prolonged post-ictal confusion which proved to be continuous complex partial status epilepticus. A 33 year old male with intractable medial temporal lobe epilepsy exhibited this ictal EEG recording. After repetitive habitual complex partial seizures, and an ensuing short lucid interval with intact memory and full communicability, the patient became mo...

Opiates have complex effects on seizure thresholds as these substances have both anti and proconvulsive actions in the mammalian brain. A reduction of inhibitory synaptic activity or enhancement of excitatory synaptic activity would be expected to trigger a seizure. This study is designed to determine how morphine and naloxone affect seizures induced by a low Mg2+ perfusate in the whole, intact...

OBJECTIVE The objective of this retrospective study is to analyze ictal patterns observed during continuous Video-EEG monitoring in patients with temporal lobe epilepsy (TLE) due to unilateral hippocampal sclerosis (HS), and to correlate these EEG patterns to temporal pole abnormalities observed on magnetic resonance imaging exams. METHODS We analyzed 147 seizures from 35 patients with TLE an...

Ictal-induced cardiac bradyarrhythmia and asystole is a rare phenomenon. The exact mechanism of ictal-induced remains unclear. It was postulated that stimulation central autonomic network during ictal episode may trigger an abrupt burst hypervagotonia. Prolonged result in syncope or death due to impairment cerebral perfusion. role cardioneuroablation (CNA) this condition has not been well-descr...

Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion observed is produced by diffusion of ictal activity. Here we describe a patient studied with v-EE...