Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with HCC827 cells, which were transfected with anti-miR-22, followed by the treatment of BPI-20...

Background: Miliary lung adenocarcinomas are rare and highly aggressive in nature. There is currently no effective treatment for this carcinoma. Case presentation: We report a very rare case of a 48-year-old man with a lung adenocarcinoma. CT findings were indicative of miliary tuberculosis. Whole body bone scans and head MRI showed multiple multiple brain and bone metastases. The patient under...

Anaplastic lymphoma kinase (ALK) rearrangement lung cancer responds to ALK tyrosine kinase inhibitors. It is known that many cases ultimately acquired resistance to crizotinib. However, a case of primary resistance is rare. We present a case of harboring exon 19 deletion in epidermal growth factor receptor in ALK rearranged lung adenocarcinoma, who experienced a partial tumor response to icotin...

Concurrent chemoradiotherapy (CRT) based on cisplatin is recognized as the current standard treatment for locally advanced cervical cancer. The of cancer has reached a plateau in last 20 years. Previous studies have proven that epidermal growth factor receptor correlated with chemo- and radioresistance failure. Hence, purpose this study was to investigate efficacy safety icotinib combined CRT E...

Epidermal growth factor receptor (EGFR) is frequently overexpressed in multiple malignancies. Icotinib (IH), a new EGFR tyrosine kinase inhibitor, enhances radiosensitivity various types of cancer, but its effect on nasopharyngeal carcinoma (NPC) remains unclear. Total 115 NPC tissue sections and 30 nasopharyngitis were enrolled. The correlation expression clinicopathologic features was analyze...

Lung cancer is the leading cause of cancer-related mortality worldwide. The most common sites of lung cancer metastasis are the lymph nodes, brain, liver, bones, and adrenal glands, whereas the gastrointestinal (GI) tract is rare. Here we report two cases of non-small cell lung cancer with GI metastases. Both patients were given epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-T...