Peroxisomes are ubiquitous eukaryotic organelles housing diverse enzymatic reactions, including several that produce toxic reactive oxygen species. Although understanding of the mechanisms whereby enzymes enter peroxisomes with the help of peroxin (PEX) proteins is increasing, mechanisms by which damaged or obsolete peroxisomal proteins are degraded are not understood. We have exploited unique ...

PURPOSE To compare the long-term results (9 years) of LASIK in one eye and phakic intraocular lens (implantable contact lens [ICL]) implantation in the fellow eye of the same patient. METHODS A patient with high myopia underwent LASIK with a MEL 60 excimer laser in one eye (spherical equivalent refraction -9.75 diopters [D], 5-mm optical zone with no transition zone) and phakic intraocular le...

Idiopathic CD4+ T-lymphocytopenia (ICL) is a new disease entity characterized by CD4+ T-lymphocyte depletion without evidence of HIV infection. We report a 27-year-old ICL patient with a long history of multiple immune abnormalities. His CD4+ T-lymphocyte count started to decrease after generalized lymphadenopathy of an unknown cause at age 3. He satisfied the criteria for ICL at age 9, and the...

A novel inductive logic programming system, called Classic’cl is presented. Classic’cl integrates several settings for learning, in particular learning from interpretations and learning from satisfiability. Within these settings, it addresses predictive, descriptive and probabilistic modeling tasks. As such, Classic’cl (C-armr, cLAudien, icl-S(S)at, ICl, and CLlpad) integrates several well-know...

Purpose: To investigate the causes of Implantable Collamer Lens (ICL) explantation and study the visual outcomes after further management in a retrospective case series. Methods: Retrospective chart review was performed for all the eyes that underwent bilateral or unilateral ICL explantation between March 2010 and April 2015. Incidence & causes of explantation, time between primary & secondary ...

The properties of the autonomically regulated chloride current (ICl) were studied in isolated guinea pig ventricular myocytes. This current was elicited upon exposure to isoproterenol (ISO) and reversed upon concurrent exposure to acetylcholine (ACh). ICl was time independent and exhibited outward rectification. The responses to ISO and ACh could be blocked by propranolol and atropine, respecti...

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) repair. Here, we have examined the role of the PTEN phosphatase in this process. We have established that PTEN-deficient cells, like FA cells, exhibit increased cytotoxicity, chromosome structural aberrations, and error-pr...

IFN-inducible CXCR3 ligands (ICL), namely CXCL9, CXCL10 and CXCL11, exhibit pleiotropic roles in orchestrating immunity and angiogenesis. However, the prognosis value of them in renal cell carcinoma (RCC) was still obscure. Thus, we retrospectively used immunohistochemistry approach to evaluate the impact of these ligands on recurrence and survival of non-metastatic clear cell RCC (ccRCC) patie...

Purpose: The purpose of the current study was to investigate the pathogenesis of visual fatigue in patients after implantable collamer lens (ICL) implantation based on an evaluation of accommodation function. Methods: Thirty patients (12 males and 18 females) with high myopia underwent a toric or non-toric ICL procedure. Accommodation function was tested pre-operatively and 1, 3, and 6 months p...