BACKGROUND Ceramide (Cer) and sphingosine (Sph) interfere with critical cellular functions relevant for cancer progression and cell survival. While Cer has already been investigated as a potential drug target for lymphoma treatment, information about the potency of sphingosine is scarce. The aim of this study therefore was to evaluate Sph and its synthetic stereoisomer L-threo-sphingosine (Lt-S...

Let X be a finite CW-complex. Denote by Sph(X) the abelian group of stable fibre-homotopy classes of spherical fibrations on X. Let F (n) be the monoid of self-homotopy-equivalences of S and let F := colimn→∞ F (n). The classifying space BF represents Sph(X), i.e. Sph(X) ∼= [X;BF ]. For any vector bundle ξ on X, let J(ξ) ∈ Sph(X) be the stable fibre homotopy class of the spherical fibration ξ \...

In this paper, the applications of mesh-free SPH (Smoothed Particle Hydrodynamics) methodology to the simulation and analysis of 3-D hard machining process is presented. A Langrangian SPH based model is carried out using the Ls-Dyna software. Classical Lagrangian, Eulerian and ALE methods such as finite element methods (FEM) cannot resolve the large distortions very well. Conventional finite el...

The objective of the present study is to develop and investigate the swelling behavior of pH-sensitive Superporous Hydrogel (SPH) and SPH composite (SPHC). A novel superporous hydrogel containing poly (methacrylic acid-co-acrylamide) was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using N,N-methylenebisacrylamide as a crosslinker and ammonium pe...

Secretory type II phospholipase A2 (sPLA2) is inhibited by sphingomyelin (SPH); cholesterol either mixed with the model glycerophospholipid substrate or added to the assay medium as separated liposomes counteracts this inhibition efficiently. The inhibition of fatty acid release assayed by quantitative gas chromatography-MS is observed when SPH is added to erythrocyte membranes as the substrate...

We present an application of SPH to saturated soil problems. Herein, the standard SPH formulation was improved to model saturated soil. It is shown that the proposed formulation could yield several advantages such as: it takes into account the pore-water pressure in an accurate manner, it automatically satisfies the dynamics boundary conditions between submerged soil and water, and it reduced t...

1. INTRODUCTION If F is a finite family of sets, then the intersection graph r(F) is the graph with vertex-set F and edges the unordered pairs C, D of distinct elements of F such that C n D # 0. It is easy to see [6, p. 19] that every graph G is isomorphic to some intersection graph T(F). Some interesting classes of graphs have arisen by letting F range over families of balls in some metric spa...

In this paper, an SPH method based on the SPH–ALE formulation is used for modelling two-phase flows with large density ratios and realistic sound speeds. The SPH scheme is further improved to circumvent the tensile instability that may occur in the SPH simulations. The two-phase SPH solver is then used to model a benchmark problem of liquid impact on a rigid wall. The results are compared with ...

Smoothed particle hydrodynamics (SPH) is a Lagrangian method based on a meshless discretization of partial differential equations. In this review, we present SPH discretization of the Navier-Stokes and advection-diffusionreaction equations, implementation of various boundary conditions, and time integration of the SPH equations, and we discuss applications of the SPH method for modeling pore-sc...

Further development and additional details and tests of Adaptive Smoothed Particle Hydrodynamics (ASPH), the new version of Smoothed Particle Hydrodynamics (SPH) described in Shapiro et al. (1996; Paper I) are presented. The ASPH method replaces the isotropic smoothing algorithm of standard SPH, in which interpolation is performed with spherical kernels of radius given by a scalar smoothing len...