conclusions the application of 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht6 and 5-ht7 receptor antagonists, applied at concentrations lower than 1.0 µm did not modify the efs-induced contraction and relaxation responses, whichsuggests the unlikely involvement of endogenous 5-ht in mediating responses to efs in the described test conditions. materials and methods segments taken from the rat duodenum, jeju...

conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...

introduction: breast cancer is the most common cancer in women worldwide and her-2 is one importantly prognostic factor in this cancer. tumor markers use as a criterion for predicting recurrence, but in breast cancer physical examination and mammography are important factors that are recommended for following up the recurrence. the aim of this study was to assess the correlation between breast ...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

introduction: human t cell lymphotropic l.irus type i is responsible for adult t cell leukemia/lymphoma and htlv-i associated myelopathy. the aim of this study was constructing two reporter plasmids to enable us to evaluate the effects of htlv-i tax protein upon intra cellular signalling pathways which recruit creb and nfkb proteins. material and methods: a complete coding region of bacterial b...

male breast cancer is a rare disease with an increasing trend. due to limited information especially about the genetic basis of the disease in iran and the lower age of its onset, the disease requires more attention. the aim of this study was to screen the male patients with breast cancer for brca mutations as well as tissue markers of estrogen receptor (er), progesterone receptor (pr), human e...