introduction: in patients with thyroid carcinoma, radiation absorbed doses of the thyroid and surrounding tissues is important to weigh risk and benefit considerations. in nuclear medicine, the accuracy of absorbed dose of internally distributed radionuclides is estimated by different methods such as mird and direct method using tld. the aim of this study is using tld and a phantom to determine...

introduction: high-dose radioactive iodine therapy in differentiated thyroid cancer (dtc) may adversely affect the salivary gland function. this study is aimed to evaluate the effect of radioactive iodine (rai) with dose of 100 mci in dtc patients compared to lower doses of less than 30 mci in hyperthyroid cases. methods: fifty four patients (13 men and 41 women) age: 42.3±14.3 (21-71) years w...

PURPOSE The role of fusion imaging methods SPECT-CT and PET-CT is currently being investigated in radiotherapy (RT) treatment planning. SPECT and PET provide extra information for gross tumor volume (GTV) delineation. The purpose of this study was to evaluate the role of SPECT-CT in RT. METHODS SPECT-CT studies were performed in 55 patients with (99m)Tc-MIBI/Tetrofosmin (TF), with 99mTc-Nanoc...

twenty-one patients with medullary thyroid carcinoma were studied prospectively with tc-99m (v) dmsa after surgery. pentavalent dmsa scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. finally, seven patients with surgical or other imaging documentation were selected for this paper. most of these patients were asymptomatic. six patients had hypercalcitonemia and se...

Introduction: Extraosseous accumulation of 99mTc – methylene diphosphonate (MDP) may be due to neoplastic, dystrophic, hormonal, inflammatory, ischemic, traumatic or excretory disorders. 99mTc-MDP incidental thyroid uptake is not frequent and is possibly caused by the presence of dystrophic or metastatic calcification, biopsy procedure and presence of beni...

Background: Radioiodine is routinely used or proposed for diagnostic and therapeutic purposes: I, I and I for diagnostics and I and I for therapy. When radioiodine-labelled pharmaceuticals are administered to the body, radioiodide might be released into the circulation and taken up by the thyroid gland, which may then be an organ at risk. The aim of this study was to compare dosimetric properti...

UNLABELLED The aim of this study was to determine the human biodistribution and radiation dosimetry of (99m)Tc-RP527, a promising radioligand for the visualization of gastrin-releasing peptide (GRP) receptor-expressing human malignancies. METHODS Whole-body scans were obtained up to 48 h after intravenous injection of 555 MBq (99m)Tc-RP527 in each of 6 subjects. Blood samples were taken at va...

The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition protocols. Two radioactive sources were centrally and peripherally placed insid...

OBJECTIVES Use of a positron emission tomography (PET)/single-photon emission computed tomography (SPECT) system facilitates the simultaneous acquisition of images with fluorine-18 fluorodeoxyglucose ((18)F-FDG) and technetium ((99m)Tc)-tetrofosmin. However, (18)F has a short half-life, and 511 keV Compton-scattered photons are detected in the (99m)Tc energy window. Therefore, in this study, we...