The TGFb1/Smad pathway plays a critical role in cholestasis and liver fibrosis. Previous studies show that TGFb1, TNFa, and insulin inhibit cholesterol 7a-hydroxylase (CYP7A1) gene transcription and bile acid synthesis in human hepatocytes. In this study, we investigated insulin, TGFb1, and TNFa regulation of rat Cyp7a1 gene transcription. In contrast to inhibition of human CYP7A1 gene transcri...

Magnetic data is useful in both hydrocarbon exploration and mining exploration. In hydrocarbon exploration, aeromagnetic data is an effective method for locating strike-slip faulting in magnetic basement. Also, high resolution surveys enhance delineation of both subtle basement features and intrasedimentary sources. In fact, magnetic methods has evolved from its sole use for mapping basement st...

شور : ،ينيلاب ييامزآراک هعلاطم نيا رد ۲۰ يحارج لمع ديدناك يندومزآ هب يموتكرتسيه دندش هداد ياج لرتنک و شيامزآ هورگ ود رد يفداصت روط . راتفر لوط رد يحارج زا شيپ يتخانش ينامرد ۸ ورگ یارب هسلج شيامزآ ه دوبهب عيرست ظاحل زا هورگ ود ره ،يحارج لمع زا سپ و دش هداد شزومآ رد يرتسب ياهزور دادعت ،يفرصم نكسم يوراد زود نازيم ينعي يمسج تيلاعف هب تشگزاب و ناتسراميب دندش يسررب هرمزور ياه . هداد شهوژپ ياه يرام...

Previous attempts to establish transgenic mouse models to study the functions of transforming growth factor b1 (TGFb1) in the skin revealed controversial roles for TGFb1 in epidermal growth (inhibition vs. stimulation) and resulted in neonatal lethality in one instance. To establish a viable transgenic model for studying functions of TGFb1 in the skin, we have now developed transgenic mice, whi...

کچ ی هد پ ی ش مز ی هن ه و فد : ساسا د مردنس رد نامرد ي سفنت سرتس ي ظنت نادازون داح ي سکا لدابت م ي و نژ د ي سکا ي د هدوب نبرک تسا طسوت هک کبس اـه ي ناـمرد ي فلتخم ي هلمجزا لکتورپ INSURE ماجنا م ي دوش ا اذل . ي هعلاطم ن فدهاب اقم ي هس عضو ي ت اه ي ندب ي عضو رب رمد و زاب قاط ي سفنت ت ي هـب لاتـبم سراـن نادازون ردنس د م ي سفنت سرتس ي لکتورپ اب نامرد تحت داح INSURE ماجنا درگ ...

صخلملا The aim of this study isto examine whether radiofrequency (RF) used in cellular phone communications at a specific absorption rate (SAR) less than 1.2 w/kg could increase the spontaneous rate of sister chromatid exchanges (SCE) or elicit alterations both in the cell replication index (CRI) and mitotic index (MI) in human peripheral blood lymphocytes. Whole blood samples were obtained fro...

سلج 36 روم 07 / 02 / 94 و يس و دصكي نيمشش يشهوژپ ياروش هسلج تروص 1 . هسلج ليكشت تعاس و خيرات ،زور : زور هبنشود خيرات هب 07 / 02 / 94 هسلج نامز تدم 2 زا تعاس 14 تياغل 16 2 . يدعب هسلج خيرات : 28 / 02 / 94 3 . هسلج ليكشت لحم : يشهوژپ تنواعم رتفد 4 . هسلج رد هدننك تكرش ءاضعا : 1 ناراجشا يلع رتكد 2 رتكد يمولظم يلع رف 3 رفدنمجرا سابع رتكد 4 يرفعج دمحم رتكد يدنره 5 يضاق ديعس رتكد يبرغم ...

BACKGROUND Activins stimulate the synthesis of follicle stimulating hormone (FSH) in pituitary gonadotropes, at least in part, by inducing transcription of its beta subunit (Fshb). Evidence from several laboratories studying transformed murine LbetaT2 gonadotropes indicates that activins signal through Smad-dependent and/or Smad-independent pathways, similar to those used by transforming growth...

BACKGROUND Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis. Transforming growth factor beta 1 (TGF beta 1) is a multifunctional cytokine that plays a key role in inflammation. Two functional single nucleotide polymorphisms (SNPs) in the TGFB1 gene have been described: TGFB1 T869C and TGFB1 G915C. OBJECTIVE To determine whether these SNPs contribute to a...