We aimed to verify the beneficial effects of probiotic strain Lactobacillus reuteri 263 (Lr263) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups: normal (n = 8), standard diet (control), and experimental (n = 32), a HCD. After a two-week i...

A rapid and sustained increase in the number of microbodies in liver and kidney cells can be induced in male rats by ethyl chlorophenoxyisobutyrate (CPIB), a hypolipidemic drug. This phenomenon permits investigation of several aspects of microbody behavior in experimental conditions. Reversal experiments demonstrate that liver cells revert to normal between 2 and 3 weeks after withdrawal of CPI...

The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipi...

Previous work in our laboratory has indicated that free fatty acids stimulate synthesis of fibrinogen by the liver. The effect of the hypolipidemic agent clofibrate on hyperfibrinogenemia associated with tumors was evaluated by monitoring clofibrateinduced changes in plasma fibrinogen concentration and bio synthesis of the protein in Buffalo rats implanted with a local ized, nonmetastasizing ne...

The beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the modulation of lipid metabolism, derived from their effect of inhibition upon HMG-CoA reductase. Statins have antiatherosclerotic effects, that positively correlate with the percent decrease in LDL cholesterol. In add...

BLACK The importance of herbal hypolipidemics has increased to fill the lacunae created by allopathic medicines. Coriander is a spice, which is used in daily cooking especially in India. In Ayurvedic literature it is reported to possess hypolipidemic activity. Hence, to validate these ancient known property researchers at International Institute of Biotechnology and Toxicology, Padappai, Tamil ...

two proprotein convertase subtilisin/kexin type 9 (PcsK9) inhibitors, evolocumab and alirocumab, have recently been approved by both the food and drug Administration (fdA) and the european Medicines Agency (eMA) for the treatment of hypercholesterolemia. these fully human monoclonal antibodies selectively block PcsK9, thus permitting the low-density lipoprotein (LdL) receptor to effectively rec...

Berberine (BBR), a kind of quaternary ammonium benzylisoquinoline alkaloids with multiple pharmacological activities, has been regarded as promising lipid-lowering agent in the field drug repurposing. Particularly, chemical modification at C-9 position BBR can remarkably improve its efficacy. In this study, thirteen novel derivatives were rationally designed, synthesized, and evaluated by preli...