Hypertrophic cardiomyopathy (HCM) is an autosomal dominant heart disease that is the most common genetic cardiac disorder. The disease is characterized by excessive thickening of the left ventricular myocardium. The anterior portion of the interventricular ventricular septum is often involved. Asymmetric hypertrophy of apical site, left ventricular free wall, and right ventricle are less common...

Background Left ventricular hypertrophy (LVH) with Left ventricular maximal thickness (LVMT) ≥15 mm as a current criteria to differentiate hypertrophic cardiomyopathy (HCM) from other causes of LVH lacks specificity. The recent findings of intrinsic mitral valve leaflet elongation in HCM may potentially distinguish HCM from other causes of LVH. We aim to studying the performance of mitral valve...

Hypertrophic cardiomyopathy corresponds to myocardial hypertrophy >15mm or >13mm in case of familial hypertrophic (HCM).We report the a 31-year-old patient with no cardiovascular risk factors and notable history who was admitted emergency room for management prolonged resting chest pain associated electrical changes electrocardiogram (EKG)given clinical symptomatology overshift mirror ima...

Apical hypertrophic cardiomyopathy (apical HCM) is a rare variant of hypertrophic cardiomyopathy with a prevalence of 1% 2% in Asian population and carries a benign prognosis. It is usually silent in early stages and manifests in adults with a suspicion of typical ECG changes of giant T wave inversion in left precordial leads. Transthoracic echocardiography is the mainstay of non-invasive diagn...

Extract: A 28-year-old asymptomatic woman was referred to ourclinic for evaluation of a heart murmur. Transthoracic echocardiography (TTE) demonstrated ventricular hypertrophy with septal thickness of 26 mm., consistent with hypertrophic cardiomyopathy (HCM). The diagnosis of HCM was confirmed by contrast-enhanced magnetic resonance imaging, and late gadolinium enhancement was observed in the a...

A 10 year old girl with hypertrophic cardiomyopathy (HCM) developed high grade atrioventricular (A-V) block unexpectedly, which instantly led to syncope; she required a permanent pacemaker. High grade A-V block, a rare complication of HCM, relates closely to syncope or sudden death in this disease and if progressive the use of cardiac pacing should be considered without delay.

Familial hypertrophic cardiomyopathy (HCM) is a disease of the sarcomere and may lead to hypertrophic, dilated, restrictive, and/or arrhythmogenic cardiomyopathy, congestive heart failure, or sudden cardiac death. We hypothesized that hearts from transgenic HCM mice harboring a mutant myosin heavy chain increase the energetic cost of contraction in a sex-specific manner. To do this, we assessed...

INTRODUCTION Severe right ventricular hypertrophy (SRVH) is a rare phenotype in hypertrophic cardiomyopathy (HCM) for which limited information is available. This study was undertaken to investigate the clinical, prognostic and genetic characteristics of HCM patients with SRVH. METHODS HCM with SRVH was defined as HCM with a maximum right ventricular wall thickness ≥10 mm. Whole-genome sequen...

D ifferentiating between young, athletic patients with hypertrophic cardiomyopathy (HCM) and elite athletes sometimes can be problematic. Left ventricular hypertrophy is seen mainly in athletes participating in endurance sports. A conflict exists with regard to strength athletes. Recent investigations suggest that strength athletes who use anabolic steroids have increased left ventricular hyper...

The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography,...