Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy Eric C. Wooten, PhD; Virginia B. Hebl, MD; Matthew J. Wolf, MD, PhD; Sarah R. Greytak, PhD; Nicole M. Orr, MD; Isabelle Draper, PhD; Jenna E. Calvino, BA; Navin K. Kapur, MD; Martin S. Maron, MD; Iftikhar J. Kullo, MD; Steve R. Ommen, MD; J. Martijn Bos, MD, PhD; Michael J. Ackerman, MD, PhD; Gordon S. Hu...

BACKGROUND Sudden cardiac death is often linked with hypertrophic cardiomyopathy in young athletes, but with a divergence of study results. We performed a meta-analysis to compare the prevalence of sudden cardiac deaths associated with hypertrophic cardiomyopathy vs sudden cardiac deaths associated with structurally normal hearts. METHODS A structured search of MEDLINE was conducted for studi...

INTRODUCTION Background: The actual prognosis of hypertrophic cardiomyopathy, a disorder previously thought of to be notorious for an increased risk of untimely death is poorly defined. Objective: The present study describes the findings of patients with Hypertrophic Cardiomyopathy followed for more than nineteen years in a large clinic population. Materials and Methods: A clinic population of ...

Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different geneti...

Hypertrophic cardiomyopathy is a fascinating disease entity in which hypertrophy of the myocardium occurs, primarily as a result of mutations of genes encoding the cardiac sarcomere.1–3 Our knowledge of patients with this unique disease of the heart muscle has advanced significantly. Once thought to be a rare malignant disease with a high risk of sudden death, population studies have revealed h...

Pheochromocytomas are rare catecholamine secreting neuroendocrine tumors that can cause intracerebral hemorrhage sometimes and very rarely cardiomyopathy simulating hypertrophic obstructive cardiomyopathy. We report a case of combination these clinical complications occurring in patient with pheochromocytoma. This illustrates importance early recognition classic symptoms excess young patients h...

Many patients with hypertrophic cardiomyopathy experience chest pain, and some of these patients are diagnosed with acute myocardial infarction. Acute myocardial infarction in the setting of hypertrophic cardiomyopathy can occur without coronary atherosclerosis. Although the exact pathophysiologic mechanism of this remains unclear, some pathologic studies have suggested that small vessel corona...

Atypical and typical chest pains are common symptoms in patients with hypertrophic cardiomyopathy. Some of these chest pains seem to be caused by ischaemia. It is difficult to objectively demonstrate ischaemia in hypertrophic cardiomyopathy. The first line treatment for chest pain considered to be ischaemic in patients with hypertrophic cardiomyopathy is the use of either a beta blocker or calc...