Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the pl...

Hypericum perforatum is an herb whose use dates back centuries. Extracts of the plant are available as over-the-counter treatment options for depression. The genus consists approximately 500 species, most which have not yet been studied. Antimicrobial resistance has reached alarming levels, indicating a post-antibiotic era many become less effective. For this reason, nine species were studied t...

Hypericum perforatum (HP), better known as St. John's Wort, has been used clinically for centuries. Modern usage is still quite diverse and includes kidney and lung ailments, insomnia and depression. Standardised extracts of HP are widely used in the treatment of psychovegetative disorders and especially for mild forms of depression. Several bioactive constituents of this plant may play importa...

The effect of the gene dosage on the expression of rRNAs was studied in Hypericum perforatum. The methylation levels of rDNA were analysed using the isoschizomers MspI and HpaII and eleven additional methylation-sensitive enzymes. No differences in rDNA methylation were observed between diploids and tetraploids at an early ontogenetic stage.

OBJECTIVE Hypericum perforatum (St. John's Wort) has long been used in traditional medicine to treat a variety of internal and external ailments. The present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of H. perforatum. MATERIALS AND METHODS Twenty male BALB/c-mice were randomly allocated in two equal groups and immunized with sheep red blood cells (...

BACKGROUND/OBJECTIVES This study was conducted to assess the potential of St. John's Wort (Hypericum perforatum) to prevent obesity and abnormalities in lipid metabolism induced by ovariectomy in a rat model without stimulatory activity on uterus. MATERIALS/METHODS Ovariectomized (OVX) rats were treated for 6 weeks with 70% ethanol extracts of Hypericum perforatum [HPEs: whole plant (WHPE) an...

St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we show that hyperforin, a constituent of St. John's wort with antidepressant activity, is a potent ligand ...

The purpose of this study was to investigate the effects of treatment with water, n-butanol and ether extracts of Hypercom perforatum L. on epileptogenesis in rabbits. Animals from the control group received solvent-ethanol, and the kindling model of epilepsy was used. Epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus. The following parameters were determined: ...