A 10-year-old Japanese girl presented with multiple, small, flat, dark brown clusters of retinal pigment epithelium in both eyes. She had no other symptoms. The appearance was consistent with congenital grouped pigmentation of the retina or bear track spots. A unique co-existing feature was the presence of small, albinotic spots within the entire retina. Fluorescein angiography demonstrated a p...

Two patients evaluated for metamorphopsia were noted to have inferotemporal retinal pigment epithelium elevations formed by a yellowish lesion. Fluorescein angiography showed granular hyperfluorescence with late leakage, which was interpreted as an occult choroidal neovascularization. One patient underwent photodynamic therapy. In both patients, neither vitreous cells nor neurologic manifestati...

We report the case of a 52-year old man with no previous significant medical history presenting with progressive decrease in visual acuity (VA) of the right eye evolving over 10 years. Corrected visual acuity was 2/10 P6 in the RE and 10/10 P2 in the LE. The examination of the anterior segment was unremarkable. Fundus examination showed alteration of the pigment epithelium (APE) in the RE assoc...

Clinical examination of the ocular surface is commonly carried out after application of sodium fluorescein in both veterinary and medical practice by assessing the resulting 'staining'. Although localized intensely stained regions of the cornea frequently occur after exposure to 'adverse' clinical stimuli, the cell biology underlying this staining is unknown, including whether intense fluoresce...

The article ‘‘Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium,’’ by Ablonczy and colleagues, forces us to re-evaluate 2 decades of dogma, and has potentially profound implications for the role (or lack thereof) of the bisretinoid A2E in human retinal degenerations. Using the elegant new method of imaging mass spectr...

Purpose To compare the differences among clinical, demographic, and multimodal imaging features of choroidal granulomas associated with tuberculosis sarcoidosis. Design Retrospective comparative case series. Methods Clinical fundus imaging, including fluorescein indocyanine green angiography optical coherence tomography patients tuberculomas sarcoid seen at 3 tertiary care centers, were reviewe...

Purpose: Here, we report a case of benign concentric annular macular dystrophy associated with visual field defect.Case summary: A 34-year-old woman presented defect that was not accompanied by deterioration in acuity. The patient’s best-corrected acuity 1.25 both eyes. No signs anterior chamber inflammation were observed, and fundoscopy showed hypopigmentation at the fovea Annular hyperfluores...

A Correction to this paper has been published: https://doi.org/10.1038/s41566-021-00759-1.