OBJECTIVE This article represents a review of histologic and genetic findings in endometriosis and describes the mechanisms whereby genetic and non-genetic factors potentially contribute to the neoplastic progression of endometriosis. METHODS Literature review of the English language literature based on searching in the MEDLINE (PubMed) database and additional collection of reports by systema...

Although endometriosis frequently involves multiple sites in the pelvis, malignancies associated with this disease are mostly confined to the ovaries, evolving from an endometrioma. Endometriomas present a 2-3-fold increased risk of transformation in clear-cell, endometrioid, and possibly low-grade serous ovarian cancers, but not in mucinous ovarian cancers. These last cancers are, in some aspe...

The aim of the study was to investigate effect obesity on development cancer certain localizations in patients with type 2 diabetes mellitus (T2D) and explain association mechanisms cancer. included retrospective analysis first time diagnosed cases T2D 2012-2016 Ivano-Frankivsk region. Analysis data carried out using Statistica 12.0 (StatSoft Inc., USA) program. are presented tables as M ± SD (...

Background . Difficulties in the prevention and treatment of endometrial pathology hormone-positive breast cancer are associated with lack an unambiguous understanding mechanisms effect tamoxifen on target tissues development possible hyperestrogenism. Aim To study ovarian steroidogenesis endometrium during adjuvant therapy pre-menopausal patients hormone-dependent cancer. Materials methods All...

The patient was a 66-year-old woman, G2P2. The patient presented a chief complaint of irregular postmenopausal bleeding 1 month ago. A transvaginal ultrasonography showed that bilateral ovaries were not enlarged and uterine endometrium was thickened, measuring at 9 mm. As a result of endometrial curettage, the simple endometrial hyperplasia was revealed. A blood examination showed an elevated e...

Pelvic endometriosis, deeply infiltrating endometriosis and uterine adenomyosis share a common pathophysiology and may be integrated into the physiological mechanism and new nosological concept of 'tissue injury and repair' (TIAR) and may, in this context, just represent the extreme of a basically physiological, estrogen-related mechanism that is pathologically exaggerated in an extremely estro...

Free tail skin grafts or suspensions of viable epidermal cells have been placed in the atraumatized uterus of isologous rat hosts and allowed to "implant" of their own accord to study the possible uniqueness of this site for other than nature's transplants, i.e. conceptuses, and its response to unnatural grafts. Despite the presence of an intact endometrial epithelium, free skin grafts heal-in ...

Adjuvant endocrine therapy is an integral component of care for endocrine-dependent breast cancer. The aim of this type of therapy is to counteract the production and the action of estrogens. The ovary is the primary site of estrogen production in premenopausal women, whereas, in postmenopausal women, the main source of estrogens is adipose tissue. Therefore, ovarian function suppression is an ...

27 Background. The objectives of this study were to determine the effectiveness the 28 effectiveness of post-polypectomy hysteroscopic endometrial resection in preventing the 29 recurrence of endometrial polyps in post-menopausal patients and analyse the 30 complications and necessity of additional surgery in patients, in addition to their degree 31 of satisfaction. 32 Methods. A prospective lo...

Currently available scientific evidence erroneously suggests that mutagenic weakness or loss of the BRCA1/2 genes may liberate the proliferative effects of estrogen signaling, which provokes DNA damage and genomic instability. Conversely, BRCA mutation seems to be an imbalanced defect, crudely inhibiting the upregulation of estrogen receptor expression and liganded transcriptional activity, whe...