familial hypercholesterolemia (fh) is a hereditary dislipidemia. patients present with extremely high level of low-density lipoprotein cholesterol (ldl-c), which is due to mutation in the gene of ldl receptor. homozygous patients (hofh) whose incidence is 1 in 1.000.000 are at high risk of premature aortic valve stenosis, and coronary artery atherosclerosis. in homozygous individuals cardiovasc...

introduction: hypercholesterolemia is a metabolic disorder that ultimately results in arterial sclerosis and complications like hypertension and coronary arterial diseases. various drugs have been used for the treatment of this condition and many studies are underway for introducing new drugs. chitosan and salvadora persica are two such drugs. chitosan is produced by deacetylation of chitin whi...

OBJECTIVES This study will assess the accuracy of self-reported hypertension, diabetes, and hypercholesterolemia among Korean older adults. METHODS Using data from the fourth Korean National Health Examination and Nutrition Survey (KNHANES IV, 2007-2009), we selected 7,270 individuals aged 50 years and older who participated in both a health examination and a health interview survey. Self-rep...

Obesity and metabolic syndrome are associated with several cancers, however, the molecular mechanisms remain to be fully elucidated. Recent studies suggest that hypercholesterolemia increases intratumoral androgen signaling in prostate cancer, but it is unclear whether androgen-independent mechanisms also exist. Since hypercholesterolemia is associated with advanced, castrate-resistant prostate...

An altered hormonal or chronic systemic inflammatory milieu characterizing endometriosis may result in a higher risk of hypercholesterolemia and hypertension. Conversely, elevated low-density lipoprotein in hypercholesterolemia and chronic systemic inflammation resulting from hypertension may increase the risk of endometriosis. We assessed the association of laparoscopically confirmed endometri...

Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are ...

OBJECTIVE Coronary microvessels are functionally coupled to the myocardial metabolic state. In hypercholesterolemia, the coronary vascular dysfunction extends to microvascular levels. We hypothesized that the vasodilator signal transduction from ischemic heart is impaired in the coronary microvascular wall of hypercholesterolemia. METHODS AND RESULTS Rabbits were fed with normal chow (control...

Objective—Coronary microvessels are functionally coupled to the myocardial metabolic state. In hypercholesterolemia, the coronary vascular dysfunction extends to microvascular levels. We hypothesized that the vasodilator signal transduction from ischemic heart is impaired in the coronary microvascular wall of hypercholesterolemia. Methods and Results—Rabbits were fed with normal chow (control g...

During the last decade, major changes have occurred in the approach to the diagnosis and treatment of hypercholesterolemia in children. In 1993 the National Cholesterol Education Program Expert Panel on Blood Cholesterol in Children and Adolescents recommended that selective screening for the diagnosis of hypercholesterolemia be implemented, and that diagnosed children be treated based on their...