Hydroxypropylmethylcellulose grafted with silanol groups (Si-HPMC) hydrogels are employed as 3D scaffolds to encapsulate phosphatase-modified silica nanoparticles ([email protected]). Such hybrid materials catalytically active when enzyme susbtrates diffusing through the material. Using enzyme-assisted self-assembly concept, tripeptide Fmoc-FFY is generated in situ close vicinity of [email prot...