BACKGROUND Naturally occurring gastrointestinal disease is an important cause of acute hypoproteinemia in adult horses and hydroxyethyl starch colloid fluid treatment is a component of supportive care in these cases to improve plasma volume and maintain colloid osmotic pressure (COP). The objectives of the present study were to compare 2 formulations of high molecular weight hydroxyethyl starch...

Introduction The Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial [1] showed increased mortality in patients with severe sepsis resuscitated with hydroxyethyl starch 130/0.42 (HES) vs. Ringer’s acetate. The underlying pathophysiological mechanisms are, however, not fully elucidated. The endothelium may be important for the effects of fluid therapy, and the different fluids may impa...

BACKGROUND The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase when hypotension is present, which may have implications for the choice of treatment of hypotension. Ho...

OBJECTIVES To determine whether a starch solution for volume resuscitation in a flow-based protocol improves circulatory status better than a crystalloid solution, as defined by the need for catecholamines in patients the morning after cardiac surgery, and whether this can be performed without increased morbidity. DESIGN Concealed, randomized, double-blind, controlled trial. PARTICIPANTS Tw...