In vivo studies with L-[13N]glutamate in the Walker 256 carcinosarcoma implanted under the renal capsule of female Sprague-Dawley rats demonstrate that uptake of glutamate and the rate of incorporation of the nitrogen label from this amino acid into metabolites is slower in the tumor than in nontumorous kidney tissue. Glutamate dehydrogenase, glutaminase, and alanine aminotransferase activities...

CONTEXT AND OBJECTIVE The coenzyme of aspartate aminotransferase is pyridoxal phosphate, generated from fresh vegetables containing pyridoxine. Vitamin B6-responsive sideroblastic anemia, myelofibrosis and Peyronies syndrome respond to high pyridoxine doses. The objective was to investigate the oral pyridoxine oral dose that would lead to maximized pyridoxal phosphate saturation of red cell asp...

The activity of alanine aminotransferase (ALAT) and aspartate aminotransferase (AAT) of different tissues of fingerlings of Labeo rohita under the influence of two effluents has been studied. The alanine aminotransferase activity was increased over the control in different exposed periods of tannery and distillery effluent treatments. The alanine aminotransferase in the liver showed increased a...

six hundred 1-d-old male broilers (ross 308) were assigned to four experimental groups; each was composed of 5 floor pen replications of 30 birds including control (no enalapril), 15, 30 and 60 ppm enalapril in the drinking water. from d 21 to 49, all the chicks were exposed to low ambient temperature to induce ascites. mortalities were inspected to determine the cause of death and diagnose of ...

Molecular modeling suggested that the large and small domain of mitochondrial aspartate aminotransferase might be linked by an engineered disulfide bond that could be expected to interfere with ligand-induced and syncatalytic changes in conformation and thus to assist in the elucidation of their significance for the catalytic mechanism. His-352, which is situated in the small domain close to Cy...

background: nonalcoholic fatty liver disease (nafld) includes a group of chronic liver disorders caused by irregular accumulation of fat in liver tissue. the current study aimed to evaluate chemical composition and the effect of fruit extract and essential oil of pimpinella anisum in experimental model of nafld. materials and methods: sixty rats were randomly divided into ten groups, six in eac...

Metformin is 1,1-dimethylbiguanide hydrochloride, the first-line therapy for type 2 diabetes. Additionally, several studies focused on role of metformin in antioxidant activities treatment hepatic disorders. The experimentally
 
 -based result valproic acid's liver injury, a front-line medicine epilepsy, attracted lot interest. As result, effect acid-induced redox disturbances rat tis...

background: green tea is one of the most popular beverages in the world. it is believed to have beneficial effects in the prevention and treatment of many diseases, one of which is nonalcoholic fatty liver disease (nafld). the present study investigated the effects of consumption of green tea in nafld patients. methods: this study was a double‑blind, placebo‑controlled, randomized clinical tria...

To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolate...