1,3-Butanediol is an ethanol dimer that induces systemic ketosis. It has previously been shown to increase hypoxic survival time and reduce neurologic deficit in several experimental preparations. The aim of this study was to determine if the mechanism of 1,3-butanediol-induced cerebral protection was elevation of blood ketone levels, blood glucagon levels, or both. Blood beta-hydroxybutyrate l...

The thermal degradation behavior of poly[(R)-3-hydroxybutyrate-co-16 mol%-4-hydroxybutyrate] (P(3HB-co-16 mol%-4HB)) was investigated based on spectroscopic analysis its pyrolyzates and two kinetic modeling approaches. Pyrolyzate revealed that trans-crotonic acid, cis-crotonic γ-butyrolactone, their oligomers (dimers trimers) were produced following P(3HB-co-16 mol%-4HB). analyses confirmed the...

Previously, we have shown the preferential incorporation of label from [3-‘%]acetoacetate, D-( -)-3-hydroxy[3-%]butyrate, and [2-‘4C]glucose into sterols and fatty acids in brain in Id-day-old rats. In these experiments, we assumed that the labeled metabolites would be used from the blood in the form which was injected. However, during metabolic processes, a labeled metabolite which is present ...

The arteriovenous uptake differences for glucose, lactate, pyruvate, />'hydroxybutyrate, and acetoacetate were measured in vessels across squa mine, cell carcinomas in ten selected patients with tumors of the head and neck. All tumors measured took up glucose, pyruvate, 0-hydroxybutyrate, and acetoacetate. They could either produce, take up, or main tain a constant level of lactate. These tumor...

The arteriovenous uptake differences for glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate were measured in vessels across squamous cell carcinomas in ten selected patients with tumors of the head and neck. All tumors measured took up glucose, pyruvate, beta-hydroxybutyrate, and acetoacetate. They could either produce, take up, or maintain a constant level of lactate. These tum...