The objective of the present study was to develop floating microsphere of norfloxacin in order to achieve an extended retention in the upper GIT which may enhance the absorption and improve the bioavailability. The microspheres were prepared by solvent evaporation method using different ratio of hydroxyl propyl methyl cellulose (HPMC K4M, HPMC K15M) and ethyl cellulose with drug in the mixture ...

Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulos...

Venlafaxine is a unique antidepressant that differs structurally from other currently available antidepressants. Short biological half life, low bioavailabilty and frequent administration of drug led rational for development of extended release formulation of Venlafaxine that releases the drug and maintian the plasma drug concentration for more than 12h.Polymers like Hydroxy propyl methyl cellu...

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by direct compression method using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well in combination at different concentrations. a biguanide has relatively short plasma half-life. It low absolute bioavailability. All properties were evalu...

The objective of this study was to develop a transdermal therapeutic system for meloxicam (MX) using various polymers like hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) and plasticisers by solvent casting technique. The prepared patches were evaluated for physicochemical properties, in vitro release, in vitro skin permeation and in vivo release. Th...

Article history: Received on: 15/12/2012 Revised on: 24/02/2013 Accepted on: 11/03/2013 Available online: 30/03/2013 Verapamil Hydrochloride is a calcium channel blocking anti-anginal agent. Extensive first pass metabolism, low bioavailability (~20%) and short biological half life (4.8 hrs) altogether makes it an ideal candidate for transdermal drug delivery. The objectives of this study were t...

Hydroxy propyl methyl cellulose can be used in the development of different drug delivery technology. Nowadays it is a widely used polymer and different viscosity grade of this polymer is available. The hydrophilic and hydrophobic form (both variants) of this polymer is also available. This study includes a review of this polymer on use in different drug delivery system mosty focusing on more r...