in developing countries, the domination of peripheral and dependent capitalism relations and the lack of appropriate structures and channels of attracting, this system have caused some kind of spatial-anatomic unbalances that has resulted in the appearance of single cities with national and regional prevalence. this situation is the main reason for small, medium and intermediate cities to lose ...

MOTIVATION Describing domain architecture is a critical step in the functional characterization of proteins. However, some orphan domains do not match any profile stored in dedicated domain databases and are thereby difficult to analyze. RESULTS We present here an original novel approach, called TREMOLO-HCA, for the analysis of orphan domain sequences and inspired from our experience in the u...

There are numerous examples of convergent evolution in nature. Major ecological adaptations such as flight, loss of limbs in vertebrates, pesticide resistance, adaptation to a parasitic way of life, etc., have all evolved more than once, as seen by their analogous functions in separate taxa. But what about protein evolution? Does the environment have a strong enough influence on intracellular p...

data envelope analysis (dea) is an approach to estimate the relative efficiency of decision making units (dmus). several studies were conducted in order to prioritize efficient units and some useful models such as cross-efficiency matrix (cem) were presented.  besides, a number of dea models with interval data have been developed and ranking dmus with such data was solved. however, presenting a...

We have investigated free energy landscape [MM/PBSA + normal modes entropy] of permutations in the G peptide (41-56) from the protein G B1 domain by studying six isomers corresponding to moving the hydrophobic cluster along the beta-strands (toward the turn: T1, AGEWTYDDKTFTVTET; T2, GEDTWDYATFTVTKTE; T3, GEDDWTYATFTVTKTE; toward the end: E1, WTYDDAGETKTFTVT; E2, WEYTGDDATKTETFTV; E3, WTYEGDDAT...