BACKGROUND Trimethoprim [2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine] is an antifolate drug. It selectively inhibits the bacterial dihydrofolate reductase (DHFR) enzyme. RESULTS In the crystal structures of trimethoprim (TMP)-hydrogen phthalate (1) and trimethoprim-hydrogen adipate (2), one of the N atoms of the pyrimidine ring is protonated and it interacts with the deprotonated carb...

Water has anomalous properties that emanate from its hydrogen-bond-induced structure. Most of the unique properties ofwater are related to the network of strong three-dimensional hydrogen bonds that interconnect the water molecules [1, 2]. According to Stillinger [3], water has a preferential three-dimensional tetrahedral structure containing a few free or single-bonded water molecules. A simul...

Hydrogen bond dynamics are explicated with exceptional detail using multidimensional infrared vibrational echo correlation spectroscopy with full phase information. Probing the hydroxyl stretch of methanol-OD oligomers in CCl4, the dynamics of the evolving hydrogen bonded network are measured with ultrashort (<50 fs) pulses. The data along with detailed model calculations demonstrate that vibra...

Hydrogen technologies and infrastructures might play a significant role in meeting ambitious climate and energy policy goals of the UK Government. Nonetheless, studies on hydrogen are either limited in scope in that they do not take into account the relationships with the wider energy system drivers and constraints or do not consider how a hydrogen network might develop geographically. This pap...

In the title salt, C(5)H(6)BrN(2) (+)·C(5)H(7)O(4) (-), the 2-amino-5-bromo-pyridinium cation is essentially planar, with a maximum deviation of 0.005 (3) Å. In the crystal structure, the proton-ated N atom and the 2-amino group of the cation are hydrogen bonded to the carboxyl-ate O atoms of the anion via a pair of N-H⋯O hydrogen bonds, forming an R(2) (2)(8) ring motif. The ion pairs are furt...

In the crystal structure of the title salt, 3C(5)H(6)NO(+)·HSO(4) (-)·SO(4) (2-)·H(2)O, the hydrogen sulfate ion is linked to the sulfate ion by an O-H⋯O hydrogen bond. The hydrogen sulfate-sulfate anion is a hydrogen-bond acceptor for the three independent cations and the uncoordinated water mol-ecule, the hydrogen-bonding inter-actions giving rise to a three-dimensional hydrogen-bonded networ...

Lipoxygenases (LOXs) have been implicated in cardiovascular disease. A rare single nucleotide polymorphism causing T560M exchange has recently been described and this mutation leads to a near null-variant of the enzyme encoded for by the ALOX15 gene. When we inspected the 3D-structure of the rabbit ortholog we localized T560 outside the active site and identified a hydrogen bridge between its s...