The anti-inflammatory effects of systemic cortisone (compound E) have been amply demonstrated in the treatment of rheumatoid arthritis (1, 2) and in experimental models in animals (3, 4). Similarly, the local use of cortisone in the treatment of inflammatory conditions of the eye (5, 6) and the effectiveness of this hormone in blocking the host reaction to a turpentine abscess (4) have given el...

For many years the intra-articular injection of procaine, with or without the addition of lactic acid or phosphate, has been advocated in the treatment of both rheumatoid arthritis and degenerative joint disease (osteo-arthritis), but controlled trials have been only rarely conducted. Such results as have been published (Desmarais, 1952) have not indicated any major difference between the solut...

In the following article the indications for the use of steroids in asthma are considered. The risks attendant upon such treatment are discussed. A comparison is made between the effects of the naturally occurring preparations and some of the modern synthetic analogues. The following table shows roughly equivalent doses of the various oral steroid preparations, so that comparable doses can read...

In the following article the indications for the use of steroids in asthma are considered. The risks attendant upon such treatment are discussed. A comparison is made between the effects of the naturally occurring preparations and some of the modern synthetic analogues. The following table shows roughly equivalent doses of the various oral steroid preparations, so that comparable doses can read...

BACKGROUND Therapeutic ultrasound to drive medication (phonophoresis) has been a mainstay in physical therapy. The most common drug used in phonophoresis is hydrocortisone acetate (HA). A number of studies have been done examining phonophoresis in the delivery of HA through the skin to underlying tissues; however, a study has never been done examining the absorption of HA using phonophoresis on...

In a double-blinded, randomized, clinical trial lasting two weeks in 20 patients with skin infections (Eczema, Dermatitis, and pruritus), inflammatory and Pruritic manifestations of corticosteroid responsive dermatoses Pruritus, Eczema and Atopic Dermatitis were treated and compared between 1% w/w hydrocortisone cream and reference 1% w/w cutisoft hydrocortisone acetate cream and reductions of ...

The multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...

The Hydrocortisone acetate (Figure 1) is a white crystalline powder; it melts at about 220°C with decomposition and is practically insoluble in water 1mg/100mL [2]. One method to overcome the poorly water solubility of HA is the use of cyclodextrins (CDs), which have been extensively studied [3]. CDs have been extensively used as complexing agents to improve the solubility of a variety of poorl...

The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed...