The amphoteric behavior of a system of two amphoteric components is theoretically examined; and this is shown to correspond more nearly with certain of the physical and chemical behaviors of living tissues than does the concept of a simple ampholyte.

The Merck pneumococcal (Pn) enzyme-linked immunosorbent assays (ELISAs) for measuring antibodies to 12 serotypes (serotypes 1, 3, 4, 6B, 7F, 8, 9V, 12F, 14, 18C, 19F, and 23F) were validated in 1999. Merck Laboratories developed the Pn assays using 10 microg/ml C polysaccharide, 100 microg/ml Pn polysaccharide (PnPs) 25, and 100 microg/ml PnPs 72 for preadsorption of samples, standards, and con...

Merck & Co., Inc. (Whitehouse Station, NJ), announced that it has successfully completed its $430 million acquisition of Inspire Pharmaceuticals, Inc. (Raleigh, NC). The cash tender offer for all outstanding shares (75.4%) of common stock of Inspire was completed by Monarch Transaction Corp., a wholly owned subsidiary of Merck. The deal, announced in February 2011, allows Merck to expand its op...

n engl j med 364;19 nejm.org may 12, 2011 1880 the steering committee of an imbalance in cancers. They contacted the DSMBs of IMPROVE-IT and SHARP. Merck was not informed of the imbalance. In July 2008, Merck first became aware of the imbalance after database lock and unblinding and provided that information to the SHARP and IMPROVE-IT steering committees, informing them of the need to notify r...

In this case study, DEMO was applied in a real lean six sigma project. The study was conducted in the Merck organisation, a worldwide pharmaceutical company with a research lab and plant for the production of birth control pills in the Netherlands. The case study was conducted at this site and was intended to solve “order reliability” problems. While the general cause of low order reliability w...

Orally ingested non-steroidal anti-inflammatory drugs (NSAIDs) and acid in gastric secretions are gastric irritants that co-exist at the surface of the gastric mucosa. Here, we examined the individual and combined effects of indomethacin, a typical NSAID, and hydrochloric acid on cell death in primary cultures of guinea pig gastric mucosal cells. Indomethacin alone (at concentrations less than ...

--The inhibition of the corrosion of mild steel in hydrochloric acid solutions by the extract of Artemisia Herba-Alba has been studied using gravimetric and electrochemical measurement. Inhibition was found to increase with increasing concentration of the inhibitor. Values of inhibition efficiency calculated from weight loss and potentiodynamic polarization are in good agreement. This value goe...