Microsomal aryl hydrocarbon hydroxylase 4 is known to be present and inducible by polycyclic hydrocarbons in a variety of tissues of many species in vivo (5, 6, 12, 38, 40-43), in explants of rat lung in organ culture (42), and in mammalian cell cultures (24, 25). 5,6 This enzyme system may be important in understanding carcinogenesis, drug action, and steroid metabolism (4, 10). Polycyclic hyd...