Calcific aortic valve disease (CAVD) is a chronic disorder characterized by an abnormal mineralization of the leaflets, which is accelerated in bicuspid aortic valve (BAV). It is suspected that mechanical strain may promote/enhance mineralization of the aortic valve. However, the effect of mechanical strain and the involved pathways during mineralization of the aortic valve remains largely unkn...

objective: the incidence of heart valve disease is increasing worldwide and the number of heart valve replacements is expected to increase in the future. by mimicking the main tissue structures and properties of heart valve, tissue engineering offers new options for the replacements. applying an appropriate scaffold in fabricating tissue-engineered heart valves (tehvs) is of importance since it...

The rate of redo surgeries are increasing on account of previously performed coronary artery bypass graft surgeries, aortic/ mitral valve replacement surgeries due to valve stenosis/ regurgitation, mitral valve repair for ischemic mitral regurgitation, the aging in the population, mechanical valve thrombosis and wearing out of the mechanical valves.Resternotomy, anterolateral right thoracotomy ...

BACKGROUND In patients after aortic valve surgery, the quality of life is hypothesized to be influenced by the type of the valve procedure. A cross-sectional study on the postoperative quality of life was carried out in patients after aortic valve-sparing surgery (with regards to the age of the patient), Ross procedure and mechanical aortic valve replacement. METHODS Quality of life was studi...

BACKGROUND It is suggested that in young adults the Ross procedure results in better late patient survival compared with mechanical prosthesis implantation. We performed a propensity score-matched study that assessed late survival in young adult patients after a Ross procedure versus that after mechanical aortic valve replacement with optimal self-management anticoagulation therapy. METHODS A...

IMPORTANCE In nonelderly patients with mitral disease requiring valve replacement, deciding between bioprosthetic and mechanical prosthetic valves is challenging because long-term survival and morbidity are not well defined. OBJECTIVE To quantify survival and major morbidity after mitral valve replacement in patients aged 50 to 69 years. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohor...

When mechanically induced progressive failure of rock and the associated changes in hydro fracturing process, it is difficult to track the dynamic evolution of fractures beneath the earth. To overcome this, recent developments in hydro-fracturing technique have tended to follow hybrid approaches. An attempt was made to develop an empirical relationship to predict the Fracture length in millimet...

The first mechanical heart valve prosthesis, designed by Dr Charles Hufnagel, was implanted to the descending aorta of a 30-year-old woman with severe aortic regurgitation in 1952.1 Eight years after the initial successful prosthetic valve implantation, Dr Harken sutured a prosthetic valve (Starr Edwards Valve) to the aortic annulus after removing the diseased native valve. During the ensuing y...

Mechanical and thermal modelling of the first normally-closed Parylene valve operating on electrothermal principles for rapid and wireless drug delivery was investigated. The modelling and experimental results confirm the mechanical robustness of the valve membrane. Valve opening behavior obtained by transient thermal finite element analysis are in accordance with the experimental microscopic i...

transcatheteraortic valve implantation, first introduced in 2002, has been established as an alternative modality for patients deemed not suitable for open-heart surgery. the anatomical vicinity of the atrioventricular node and the his bundle to the non-coronary and rightcoronary aortic cusps predisposes patients to conduction abnormalities in case of severe calcification or mechanical trauma d...