Many human globin-chain mutants contain amino acid replacements that result from single base changes in the corresponding globin gene. Using recombinants, the coding sequences of each of the alpha-, beta-, Ggamma-, and Agamma-globin genes have now been determined. Those sequences of DNA that are cleaved by a number of specific restriction endonucleases have been identified and accurately positi...

This report addresses the classical problem of keeping huge bitmaps predominantly consisting of long ranges of zeros and ones. The problem is most often encountered in filesystems (free space tracking) and network protocols (transmission progress tracking). Three classical solutions to the problem are plain bitmaps (NTFS), extent lists (TCP SACK) and extent binary trees (XFS, Btrfs). Bitmaps ar...

In this paper, we combine two types of local search algorithms for global optimization of continuous functions. In the literature, most of the hybrid algorithms are produced by combination of a global optimization algorithm with a local search algorithm and the local search is used to improve the solution quality, not to explore the search space to find independently the global optimum. The foc...

Aspartic proteases are a relatively small group of enzymes which express in various nematodes including Onchocerca volvulus. An estimation of the gene copy number corresponding to the OV7A clone, which contains a cDNA insert encoding approximately two-thirds of the entire coding sequence of aspartic protease of O. volvulus, was made by slot blot analysis in a closely related species O. gibsonig...

This year marks the 35th anniversary of landmark experiments, reported in Physical Review Letters [1,2], that tested one of the most bewildering predictions of quantum mechanics: Information can exist nonlocally, so that retrieving it requires performing measurements on two distinct particles that are said to be entangled. This prediction had been troubling physicists for decades. The perplexit...