With the launches of HY-2B, HY-2C and HY-2D, National Satellite Ocean Application Service (NSOAS) successfully established first batch HY-2 constellation on 19 May 2021, dedicated to detecting marine dynamic environment. While validation calibration series satellites have been well studied, using both in situ cross-track measurements, further evaluation is required mapping capability mesoscale ...

Advances in biomimetic three-dimensional (3D) melanoma models have brought new prospects of drug screening and disease modeling, since their physiological relevancy for recapitulating vivo tumor architectures is more accurate than traditional two-dimensional (2D) cell culture. Gelatin methacryloyl (GelMA) widely used as a tissue-engineered scaffold hydrogel 3D In the present study, an vitro mal...

Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell receptor signaling, regulating both T cell activation and migration of primed T cells to non-lymphoid antigen-rich tissue. We investigated the effect of genetic or pharmacolo...

The goal of this report is i) to model the occurrence and hunting yield (HY) density wild ungulates not only for widely distributed species in Europe, but also those ones which have a constrained distribution ii) compare output with observed HY. Random Forest function was used modelling species. We data available from past 30 years, HY (period 2015-2020) records collected by ENETWILD. Like prev...

Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We show that local immunostimulation performed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes rejection. We feel that this approach should be tested in tumor-bearing human patients in combination wit...

The aim of this study was to evaluate the effects of sodium hyaluronate (HY), single-walled carbon nanotubes (SWCNTs) and HY-functionalized SWCNTs (HY-SWCNTs) on the behavior of primary osteoblasts, as well as to investigate the deposition of inorganic crystals on titanium surfaces coated with these biocomposites. Primary osteoblasts were obtained from the calvarial bones of male newborn Wistar...

BACKGROUND The efficacy of rotigotine has been demonstrated in studies of patients with early (i.e. not receiving levodopa) and advanced (i.e. not adequately controlled on levodopa; average 2.5 h/day in 'off' state) Parkinson's disease (PD). OBJECTIVE To further investigate the efficacy of rotigotine transdermal patch across different stages of PD symptom severity and functional disability, a...

The poor prognosis of patients suffering from malignant glioma requires further efforts. Photodynamic therapy (PDT) might be a therapeutic option to increase surgical radicality. Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons. Therefore, the impact of various experimental parameters on cytotoxicity, in...

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant, has been shown to cause thymic atrophy and apoptosis. However, whether TCDD alters the process of T-cell selection in the thymus is not clear. To this end, we investigated the effects of TCDD in the context of the HY-T-cell receptor (TCR) transgenic (Tg) mouse model. We noted that negatively selecting male HY-TC...

In this work, the impact of chemical additions, especially nano-particles (NPs), was quantitatively analyzed using our constructed artificial neural networks (ANNs)-response surface methodology (RSM) algorithm. Fe-based and Ni-based NPs ions, including Mg2+, Cu2+, Na+, NH4+, K+, behave differently towards response hydrogen yield (HY) evolution rate (HER). Manipulating size concentration found t...