The Yoneda Lemma tells us that the Hom bifunctor is “non-degenerate” in a similar way. (a) For each object X ∈ C verify that hX := HomC(X,−) defines a functor C → Set. (b) Given two objects X,Y ∈ C state what it means to have hX ≈ hY as functors. (c) Given two objects X,Y ∈ C and an isomorphism of functors hX ≈ hY , prove that we have an isomorphism of objects X ≈ Y . [Hint: Let Φ : hX ∼ −→ hY ...

The animals were subjected to hormone treatment for 1 week. Hormones were administered either continuously via osmotic minipumps (m.p.) or intermittently by subcutaneous injections once ( 1 x s.c.) or twice (2 x s.c.) daily. Daily doses were 120 pg for GH and 100 pg for methyltrienolone, respectively. Lane I , control female; lane 2, hypophysectomized (Hx) female; lane 3, female + androgen (met...

In this work we solve a special case of the problem of building an n-dimensional parallelepiped using a given set of n-dimensional parallelepipeds. Consider the identity x = xHx 1L Hx 2L + 3 xHx 1L + x. For sufficiently large x, we associate with x3 a cube with edges of size x, with x Hx 1L Hx 2L a parallelepiped with edges x, x 1, x 2, with 3 x Hx 1L three parallelepipeds of edges x, x 1, 1, a...

Haemopexin (Hx) is an acute phase plasma glycoprotein, mainly produced by the liver and released into plasma where it binds heme with high affinity and delivers it to the liver. This system provides protection against free heme-mediated oxidative stress, limits access by pathogens to heme and contributes to iron homeostasis by recycling heme iron. Hx protein has been found in the sciatic nerve,...

Hemopexin (Hx), the major heme-binding plasma glycoprotein, scavenges circulating heme and performs an antioxidant function. In the present study, human Hx was expressed in a baculovirus system and its presumed essential His residues were mutated to Thr as a means of investigating their participation in heme binding. The recombinant Hx proteins were purified by sequential chromatography on Con ...

When released from damaged erythrocytes free heme not only provides a source of iron for invading bacteria but also highly toxic due to its ability to catalyze free radical formation. Hemopexin (Hx) binds free heme with very high-affinity and thus protects against heme toxicity, sequesters heme from pathogens, and helps conserve valuable iron. Hx is also an acute-phase serum protein (APP), whos...

Seeds from the myxospermous species Plantago ovata release a polysaccharide-rich mucilage upon contact with water. This seed coat derived mucilage is composed predominantly of heteroxylan (HX) and is utilized as a gluten-free dietary fiber supplement to promote human colorectal health. In this study, a gamma-irradiated P. ovata population was generated and screened using histological stains and...

For better design and optimization of the heat exchanger (HX), forced convective transfer flow characteristics supercritical carbon dioxide (SCO2) in a water-cooled experimental counter-flow tube-in-tube HX were studied numerically with three-dimensional Reynolds-averaged Navier-Stokes equations shear stress transport (SST) turbulence model by using computational fluid dynamics method ANSYS CFX...

Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX‐MS monitors isotopic exchange of hydrogens in protein backbone amides and thus serves as a sensitive method for probing protein conformation and dynamics along the entire protein backbone (except for proline) (Figure 1.1). Historically, the monito...

The results obtained by liver transplantation (TX) (n = 105) for hepatocellular carcinoma (HCC) were compared with those achieved by hepatic resection (HX) (n = 76). Overall 1- to 5-year survival rates after TX were 66%, 49%, 39%, 36%, and 36%, and those after HX were 71%, 55%, 47%, 37%, and 33%, respectively. The survival rates after TX and HX correlated well with pTNM stages, and the overall ...