The MHC genes encoding class II HLA-DP antigens map centromerically of the HLA-DQ loci on the short arm of chromosome six (Shaw et al. 1981). These HLA-DP antigens have originally been identified by cellular typing reagents (Shaw et al. 1980; Pawelec et al. 1982). At present, different molecular genotyping techniques are available to explore the DPB1 locus polymorphism. More allelic sequences a...

The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic and organic compounds such as beryllium, gold, acid anhydrides, isocyanates and grass pollens. Since many en...

Human leukocyte antigen (HLA), a system involved in immune response to foreign antigens and autoimmunity, has been strongly implicated multiple sclerosis (MS). Prior research shown that HLA DRB1*15:01 exerts the strongest susceptibility effect, although other alleles have both to, protection against, MS. Here we utilized an immunogenetic epidemiological approach evaluate correlations between po...

We studied the distribution of class 1 and class 2 major histocompatibility complex (MHC) antigens on bile duct epithelial cells in liver from patients with primary biliary cirrhosis (PBC) by an immunohistochemical method using monoclonal antibodies to HLA-ABC products and HLA-D subregion products (HLA-DR, -DP, -DQ). By light microscopy, the expression of MHC class 1 antigens (HLA-ABC antigens)...

Background: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. Objective: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen. Methods: A case-control study in the Urology and Nephrol...

background: human leukocyte antigens (hla) are polymorphic cell surface proteins. distribution of hla alleles vary among different racial and ethnic populations in unrelated stem cell registries. determination of hla allele frequencies in different ethnic groups is useful for population genetic analyses. materials and methods: based on data available from the iranian stem cell donor registry, h...

Highly purified populations of alveolar epithelial cells (type II pneumocytes) were isolated from human lung specimens. These cells were characterised histochemically, by demonstrating the presence of intracellular alkaline phosphatase, and morphologically, by electron microscopic demonstration of lamellar bodies and microvilli. Expression of the epithelial glycoprotein HEA-125, of MHC class I ...

Serology and DNA techniques are employed for Human Leukocyte Antigen (HLA) typing in different transplant centers. Results may not always correlate well and may need retyping with different technique. All the patients (with aplastic anemia, thalassemia, and immunodeficiency) and their donors, requiring HLA typing for bone marrow transplant were enrolled in the study. Serological HLA typing was ...

Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susc...