A central feature of herpesvirus biology is the ability of herpesviruses to remain latent within host cells. Classically, exposure to inducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduction events, and epigenetic agents (e.g., butyrate) was thought to end latency. We recently showed that Kaposi's sarcoma-associated herpesvirus (KSHV, or human he...

Human herpesvirus 8 (HHV-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. No relationship between HHV-8 infection and pulmonary hypertension was found.

Twenty two cases of human herpesvirus 7 (HHV-7) infection are described. HHV-7 infection occurred later than human herpesvirus 6 (HHV-6) infection and induced exanthem subitum in 47.1% of the children. HHV-7 infection was associated with exanthem subitum and the other symptoms that were observed in HHV-6 infection.

The combination of interleukin 2 (IL-2) and antiretroviral therapy (ART) represents an emerging strategy in the treatment of patients infected with HIV. Aside from its immunomodulatory role, however, IL-2 may induce replication of human herpesvirus 8 (HHV-8)/Kaposi sarcoma (KS)-associated herpesvirus. We retrospectively evaluated HHV-8 plasma viremia and cellular load, as well as anti-HHV-8 ant...

To determine the epidemiology of human herpesvirus type 8 (HHV-8) among non-Amazonian native populations, we conducted a cross-sectional study in Brazil, Bolivia, and Paraguay. Our data show striking ethnic and geographic variations in the distribution of HHV-8 seroprevalences in Amazonian (77%) and non-Amazonian native populations (range 0%-83%).

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

The huge amount of experimental and clinical observations supporting the possible involvement of human herpesvirus 8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) in human lymphoproliferative diseases was critically reviewed during a workshop organized by the Italian Society for Experimental Hematology in Florence, Italy, on July 3rd, 1997. The organizers have prepared this report for the reader...