Nuclear import of the human androgen receptor was investigated by immunocytochemical analysis of androgen receptor deletion and substitution mutants, which were transiently expressed in COS-1 cells. The signal responsible for nuclear import is encoded by amino-acid residues 608-625 and is functionally similar to the bipartite nucleoplasmin nuclear-localization signal. Although the subcellular d...

Galactosides as carbohydrate receptors play critical roles in biological recognition events. -Galactosyl ( -Gal) epitopes and globotriose are two representative galactosyloligosaccharides with therapeutic significance. -Gal epitopes (Gal 1,3Gal 1,4GlcOR, Fig. 1) are oligosaccharides abundantly expressed on the surface of pig vascular endothelial cells (1 10 epitopes per cell). Their interaction...

This paper addresses the problem of fast Human Activity Recognition (HAR) in visual lifelogging. We identify the importance of visual features related to HAR and we specifically evaluate the HAR discrimination potential of Colour Histograms and Histogram of Oriented Gradients. In our evaluation we show that colour can be a low-cost and e↵ective means of low-cost HAR when performing single-user ...

We performed combinatorial peptide library screening in vivo on a novel human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bonelike matrix and soft tissue. We found two peptides, PKRGFQD and SNTRVAP, which were enriched in the tumors, targeted the cell surface of androgen-independent prostate cancer cells in vitro, and homed to androgen re...

The human androgen receptor plays a major role in the development and progression of prostate cancer and represents a well-established drug target. All clinically approved androgen receptor antagonists possess similar chemical structures and exhibit the same mode of action on the androgen receptor. Although initially effective, resistance to these androgen receptor antagonists usually develops ...

The human androgen receptor plays a major role in the development and progression of prostate cancer and represents a well-established drug target. All clinically approved androgen receptor antagonists possess similar chemical structures and exhibit the same mode of action on the androgen receptor. Although initially effective, resistance to these androgen receptor antagonists usually develops ...