Serotonin [5-hydroxytryptamine (5-HT)] acts as a modulator of colonic motility and secretion. We characterized the action of the 5-HT precursor 5-hydroxytryptophan (5-HTP) on colonic myenteric neurons and propulsive motor activity in conscious mice. Fos immunoreactivity (IR), used as a marker of neuronal activation, was monitored in longitudinal muscle/myenteric plexus whole mount preparations ...

5-HTP (5 mg/100 g body weight), a precursor of serotonin, was administered intravenously to pituitary stalk sectioned rats. Plasma prolactin levels were initially increased 30 and 60 min after the injection of 5-HTP and thereafter decreased. Pituitary prolactin content was decreased 60 min after the stalk section as compared to those seen following sham operation. The treatment of 5-HTP induced...

A theoretical study of a number of chiral molecules has been undertaken using a molecular Monte Carlo simulation approach coupled with calculations of molecular chirality based on a chirality order parameter. Results for a variety of TADDOL (a ,a ,a8,a8-tetraaryl-1,3-dioxolan-4,5dimethanol! derivatives show good agreement with experimental findings for the sign, magnitude, and the temperature d...

5-HT) plays an important role in the central nervous system and that 5-HT participates in neurological disorders such as depression, anxiety or schizophrenia. Several drugs affecting serotonergic neurons are administered as therapy of these diseases. 5-HT is also a significant factor of regulation of food intake. A serotonin-releasing drug fenfluramine and selective serotonin reuptake inhibitor...

Transplantable cloned HTP/Cl culture was a stable line derived from a rat uterine adenocarcinoma that was induced by 7,12-dimethylbenz(a)anthracene in vivo and did not display density-dependent inhibition of growth. This HTP/Cl culture easily adapted to grow in a culture medium containing progesterone, 8 mug/ml. As compared with HTP/Cl culture, HTP/Cl/P8 culture grown in the presence of progest...

The present study investigates the role of serotonin in respiratory recovery after spinal cord injury. Experiments were conducted on C(2) spinal cord hemisected, anesthetized, vagotomized, paralyzed, and artificially ventilated rats in which end-tidal CO(2) was monitored and maintained. Before drug administration, the phrenic nerve ipsilateral to hemisection showed no respiratory-related activi...

L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science....

Used the House-Tree-Person as a measure of pathology in 10 schizophrenic patients of both sexes between the ages of 19 and 30 before and after experimental hemodialysis treatment. Results obtained through the quantitative HTP scoring method, and reflected in HTP IQs, indicate that significant improvement as a function of treatment is seen in pre- to post-dialysis drawings. Data analysis, using ...

We examine and propose a solution to the problem of recovering a block sparse signal with sparse blocks from linear measurements. Such problems naturally emerge in the context of mobile communication, in settings motivated by desiderata of a 5G framework. We introduce a new variant of the Hard Thresholding Pursuit (HTP) algorithm [1] referred to as HiHTP. For the specific class of sparsity stru...